Mitochondrial matrix-localized p53 participates in degradation of mitochondrial RNAs
| Autor: | Dror Avni, Yael Friedman, Amnon Hizi, Mary Bakhanashvili |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Exonuclease RNA Mitochondrial R-loop RNA Stability Oxidative phosphorylation Mitochondrion 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Humans Molecular Biology biology Chemistry RNA Cell Biology Mitochondria Cell biology 030104 developmental biology Mitochondrial matrix biology.protein Molecular Medicine Tumor Suppressor Protein p53 Exoribonuclease activity 030217 neurology & neurosurgery DNA |
| Zdroj: | Mitochondrion. 58:200-212 |
| ISSN: | 1567-7249 |
| DOI: | 10.1016/j.mito.2021.03.007 |
| Popis: | Mitochondrial RNA degradation plays an important role in maintenance of the mitochondria genetic integrity. Mitochondrial localization of p53 was observed in non-stressed and stressed cells. p53, as an RNA-binding protein, exerts 3'→5' exoribonuclease activity. The data suggest that in non-stressed cells, mitochondrial matrix-localized p53, with exoribonuclease activity, may play a housekeeping positive role. p53, through restriction the formation of new RNA/DNA hybrid and processing R-loop, might serve as mitochondrial R-loop suppressor. Conversely, stress-induced matrix-p53 decreases the amount of mitochondrial single-stranded RNA transcripts (including polyA- and non-polyA RNAs), thereby leading to the decline in the amount of mitochondria-encoded oxidative phosphorylation components. |
| Databáze: | OpenAIRE |
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