Central visual function and inner retinal structure in primary open-angle glaucoma

Autor: Vance Zemon, Yuanbo Liang, Yan-Qian Xie, Sha-Ling Li, Li-Juan Xu
Rok vydání: 2020
Předmět:
0301 basic medicine
Adult
Male
medicine.medical_specialty
Open angle glaucoma
genetic structures
Nerve fiber layer
Glaucoma
Signal-To-Noise Ratio
General Biochemistry
Genetics and Molecular Biology
Retina
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Optical coherence tomography
Ophthalmology
medicine
Humans
Macula Lutea
General Pharmacology
Toxicology and Pharmaceutics
Ganglion cell layer
Aged
General Veterinary
medicine.diagnostic_test
business.industry
Retinal
General Medicine
Middle Aged
Inner plexiform layer
medicine.disease
eye diseases
030104 developmental biology
medicine.anatomical_structure
Retinal structure
chemistry
030220 oncology & carcinogenesis
Evoked Potentials
Visual
Female
sense organs
business
Glaucoma
Open-Angle
Tomography
Optical Coherence
Zdroj: Journal of Zhejiang University. Science. B. 21(4)
ISSN: 1862-1783
Popis: To investigate associations between central visual function and inner retinal structure in primary open-angle glaucoma (POAG). This study enrolled 78 POAG patients and 58 healthy controls. POAG was classified into early glaucoma and moderate to advanced glaucoma. The following tests were performed on all participants: isolated-check visual evoked potential (icVEP) testing, 24-2 standard automated perimetry (SAP), and Cirrus optical coherence tomography (OCT) examinations. Signal-to-noise ratio (SNR) measures obtained from icVEP responses to isolated checks presented at four depths of modulation (DOMs; 8%, 14%, 22%, and 32%) were explored. Mean macular sensitivity (mMS) was assessed by calculating the mean sensitivities of central 12 SAP points. Ganglion cell layer+ inner plexiform layer thickness (GCL+IPLT) and peripapillary retinal nerve fiber layer thickness (pRNFLT) were measured by OCT scanning. For each group of subjects, linear relationships among the following measures were analyzed: SNR, mMS, GCL+IPLT, and pRNFLT. SNR, mMS, GCL+IPLT, and pRNFLT were all more significantly decreased in glaucoma than in controls (P
Databáze: OpenAIRE
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