A High Ki67/BCL2 Index Could Predict Lower Disease-Free and Overall Survival in Intestinal-Type Gastric Cancer
Autor: | Yun Ju Jo, Sang Bong Ahn, Young Sook Park, Jinwon Seo, Donghyun Kim, Kyueng-Whan Min, Junghoon Ha, Dong-Hoon Kim, Eun Kyung Kim, Byoung Kwan Son |
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Rok vydání: | 2017 |
Předmět: |
Male
0301 basic medicine Oncology medicine.medical_specialty Disease free Adenocarcinoma Biology Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms hemic and lymphatic diseases Internal medicine Republic of Korea medicine Overall survival Humans Neoplasm Metastasis Ki67 antigen Aged Retrospective Studies Intestinal type Stomach Cancer medicine.disease Ki-67 Antigen 030104 developmental biology medicine.anatomical_structure Proto-Oncogene Proteins c-bcl-2 030220 oncology & carcinogenesis Female Surgery Bcl-2 Homologous Antagonist-Killer Protein |
Zdroj: | European Surgical Research. 58:158-168 |
ISSN: | 1421-9921 0014-312X |
Popis: | Background: The heterogeneity of gastric cancer makes the identification of potential prognostic indicators particularly important. The Ki67 and BCL2 proteins are known prognostic markers for different types of cancer. Ki67 is associated with cell proliferation, whereas BCL2 has antiproliferative roles. A combined marker based on these opposite functions might provide improved prognostic information in gastric cancer. Method: Ki67 and BCL2 expression was assessed in 276 gastric adenocarcinoma tissue microarrays. A Ki67/BCL2 index based on the relative expression of each protein was divided into low- and high-risk groups using receiver operating characteristic curves. Results: A high Ki67/BCL2 index significantly correlated with advanced stage, recurrence, intestinal type, high histologic grade, and lymphatic and perineural invasion (all p < 0.05). Univariate and multivariate analyses revealed a significant relationship between disease-free or overall survival and the Ki67/BCL2 index in intestinal-type gastric cancer (all p < 0.05). Conclusions: A combined marker using Ki67 and BCL2 could be a useful indicator for predicting survival in patients with intestinal-type gastric cancer. |
Databáze: | OpenAIRE |
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