Identification of an abnormal esophageal clearance response to intraluminal distention in patients with esophagitis
| Autor: | Venk Mani, David G. Thompson, Timothy O'Hanrahan, Leslie Heggie, David J. Williams, Margaret Marples, John Bancewicz |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Manometry Sensation Balloon Gastroenterology Esophagus Internal medicine medicine Humans Reflux esophagitis Esophagitis Peptic Peristalsis Hepatology Esophageal disease business.industry Reflux Age Factors Middle Aged medicine.disease Dilatation Pathophysiology medicine.anatomical_structure Cardiology Female business Esophagitis |
| Zdroj: | Gastroenterology. 103(3) |
| ISSN: | 0016-5085 |
| Popis: | Esophageal clearance responses were studied by a new technique comprising a miniature electronic strain gauge attached to an inflatable balloon in 30 normal volunteers and 48 patients with gastroesophageal reflux disease. The pressure changes around the balloon and traction forces acting on the balloon were measured during graded balloon distention (0-12 mL of air for 30 seconds each inflation) in the lower and midesophagus. All normal volunteers responded to distention with development of swallow independent contractions above the balloon [65 mm Hg/30 s (range, 45-100 mm Hg/30 s)] together with generation of an aboral traction force [15 g (range, 9-20 g)]. Patients with reflux esophagitis showed a higher distention threshold for initiation of these responses, induced fewer proximal contractions [24 mm Hg/30 s (range, 0-38 mm Hg/30 s); P less than 0.01 vs. normal], and generated weaker traction forces [4 g (range, 0-6 g) at 10 mL P less than 0.01 vs. normal]. Patients with the most severe esophagitis showed greatest impairment of the clearance response (correlation = 0.7, P less than 0.01) and the greatest esophageal residence of refluxed acid (correlation = 0.5, P less than 0.01). These abnormalities appear to be of relevance to the pathophysiology of esophageal reflux disease although it remains to be determined whether they are the cause, or the result, of the esophagitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|