Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy
| Autor: | Camiel J. F. Boon, Sascha Fauser, Carel B. Hoyng, Elon H. C. van Dijk, Danial Mohabati, Greet Dijkman, Eiko K. de Jong, Suzanne Yzer, José P Martinez-Ciriano, Myrte B. Breukink, Thomas J. van Rijssen |
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| Přispěvatelé: | Ophthalmology, ANS - Cellular & Molecular Mechanisms |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Retinal degeneration medicine.medical_specialty Visual acuity chronic central serous chorioretinopathy genetic structures medicine.medical_treatment Photodynamic therapy Chronic central serous chorioretinopathy Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12] therapeutic outcome 03 medical and health sciences 0302 clinical medicine All institutes and research themes of the Radboud University Medical Center Ophthalmology medicine posterior cystoid retinal degeneration Effective treatment Original Research Retinal pigment epithelium medicine.diagnostic_test severe phenotype business.industry Clinical Ophthalmology Diabetic retinopathy medicine.disease Fluorescein angiography eye diseases 030104 developmental biology medicine.anatomical_structure photodynamic therapy 030221 ophthalmology & optometry sense organs medicine.symptom business |
| Zdroj: | Clinical ophthalmology (Auckland, N.Z.), 12, 2167-2176. Dove Medical Press Ltd. Clinical Ophthalmology, 12, 2167-2176 Clinical Ophthalmology (Auckland, N.Z.) Clinical Ophthalmology, 12, pp. 2167-2176 Clinical Ophthalmology |
| ISSN: | 1177-5467 |
| Popis: | Danial Mohabati,1,2 Elon HC van Dijk,1 Thomas J van Rijssen,1 Eiko K de Jong,3 Myrte B Breukink,3 Jose P Martinez-Ciriano,4 Greet Dijkman,1 Carel B Hoyng,3 Sascha Fauser,5 Suzanne Yzer,4 Camiel JF Boon1,6 1Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands; 2Department of Ophthalmology, Rotterdam Ophthalmic Institute, Rotterdam, the Netherlands; 3Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; 4Department of Ophthalmology, The Rotterdam Eye Hospital, Rotterdam, the Netherlands; 5Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany; 6Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands Purpose: To describe a spectrum of severe chronic central serous chorioretinopathy (cCSC) cases and their response to photodynamic therapy (PDT).Patients and methods: A total of 66 patients (81 eyes) with active severe cCSC were studied, and their response to PDT was compared with a control group consisting of 35 active cCSCs (37 eyes) that did not display characteristics of severity. Best-corrected visual acuity (BCVA) and complete resolution of subretinal fluid (SRF) were considered as main outcome measures.Results: In severe cCSC cases, we found cumulative areas of diffuse atrophic retinal pigment epithelium alterations in 48 eyes (59%), multiple “hot spots” of leakage in 36 eyes (44%), posterior cystoid retinal degeneration in 25 eyes (31%), and 13 eyes (16%) had a diffuse leakage on fluorescein angiography. After PDT treatment, BCVA increased in both groups, from 66 to 72 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters in the case group (P |
| Databáze: | OpenAIRE |
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