One-Pot Transformation of Furans into 1-Azaspirocyclic Alkaloid Frameworks Induced by Visible Light
| Autor: | Artemis Bosveli, Tamsyn Montagnon, Stela Hoxha, Georgios Vassilikogiannakis, Dimitris Kalaitzakis |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Molecular complexity
010405 organic chemistry Organic Chemistry Stemonamine Cylindricine 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Transformation (music) 0104 chemical sciences Solvent chemistry.chemical_compound chemistry Furan Lepadiformine Physical and Theoretical Chemistry Visible spectrum |
| Zdroj: | Organic Letters. 23:5354-5358 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.1c01661 |
| Popis: | High-value 1-azaspirocyclic scaffolds have been made from simple and readily accessible furan precursors in a single operation. The protocol is a one-pot sequence using highly sustainable conditions (oxygen, visible light, and a favored green solvent) that leads to a dramatic increase in molecular complexity. The initial substrates can include functionalities that are suitable for further elaboration; in this way, the pruned polycyclic skeletons of the stemonamine, cylindricine, and lepadiformine natural products were rapidly accessed. |
| Databáze: | OpenAIRE |
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