Increased Levels of 25 Hydroxyvitamin D and 1,25-Dihydroxyvitamin D After Rosuvastatin Treatment: A Novel Pleiotropic Effect of Statins?
| Autor: | Hicran Cil, Bunyamin Yavuz, Emre Tutal, Kursad Dal, Naim Ata, Murat Sevket Hokkaomeroglu, Kadir Okhan Akin, Derun Taner Ertugrul, Metin Kucukazman, Ahmet Arif Yalcin, Burcu Balam Yavuz |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Vitamin medicine.medical_specialty Statin medicine.drug_class Hyperlipidemias Gastroenterology Bone and Bones Cohort Studies chemistry.chemical_compound Internal medicine Diabetes Mellitus medicine Vitamin D and neurology Humans Pharmacology (medical) Rosuvastatin Prospective Studies Rosuvastatin Calcium Vitamin D Prospective cohort study Aged Pharmacology Sulfonamides biology business.industry Cholesterol nutritional and metabolic diseases General Medicine Middle Aged Alkaline Phosphatase Fluorobenzenes Pyrimidines Endocrinology chemistry Hypertension HMG-CoA reductase biology.protein Female Hydroxymethylglutaryl-CoA Reductase Inhibitors Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Cardiovascular Drugs and Therapy. 23:295-299 |
| ISSN: | 1573-7241 0920-3206 |
| Popis: | Low levels of 25-hydroxyvitamin D are associated with higher risk of cardiovascular morbidity and mortality. Large trials demonstrated that statins significantly decrease cardiovascular morbidity and mortality. 7-dehydrocholesterol is the precursor of both cholesterol and vitamin D. The aim of this study was to investigate the possible effect of rosuvastatin on vitamin D metabolism. The study was performed in a prospective cohort design. The study group consisted of 91 hyperlipidemic patients who had not been treated with lipid lowering medications. Lipid parameters, 25 hydroxyvitamin-D, 1,25-dihydroxyvitamin D, and bone alkaline phosphatase were obtained at baseline and after 8 weeks of rosuvastatin treatment. None of the subjects withdrew from the study because of the adverse effects. The mean age was 59.9 ± 12.5 years. The majority of the patients were male (55, 60%). Seventeen patients were diabetic, and 43 patients had systemic hypertension. There was a significant increase in 25-hydroxyvitamin D, from mean 14.0 (range 3.7– 67) to mean 36.3 (range 3.8 –117) ng/ml (p |
| Databáze: | OpenAIRE |
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