Molecular forms of adrenomedullin in pericardial fluid and plasma in patients with ischaemic heart disease
| Autor: | Yasushi Matsushita, Yoshitaka Okamura, Shigeo Horinaka, Hiroaki Matsuoka, Hiroshi Iida, Toshio Nishikimi, Ikuko Shibasaki, Hideaki Mori, Koichiro Shimada, Yoshihiko Mochizuki, Kenji Kangawa, Hiroshi Asakawa |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Inotrope medicine.medical_specialty Myocardial Ischemia Coronary Disease Vasodilation Pericardial Effusion Ventricular Function Left Adrenomedullin Atrial natriuretic peptide Internal medicine Natriuretic Peptide Brain Cyclic AMP Humans Medicine Pericardium Coronary Artery Bypass Aged Aged 80 and over business.industry Pericardial fluid General Medicine Middle Aged Brain natriuretic peptide medicine.anatomical_structure Endocrinology Cardiology Female Immunoradiometric Assay Peptides business Atrial Natriuretic Factor Artery |
| Zdroj: | Clinical Science. 102:669-677 |
| ISSN: | 1470-8736 0143-5221 |
| DOI: | 10.1042/cs1020669 |
| Popis: | Experimental studies have demonstrated that adrenomedullin (AM) has a positive inotropic action and exerts inhibitory effects against ventricular remodelling as an autocrine and paracrine factor. However, there is no clinical evidence for AM acting as a local regulator in the human heart. We measured the levels of various molecular forms of AM, i.e. an active form of mature AM (AM-m), an intermediate inactive form of glycine-extended AM (AM-Gly) and total AM (AM-T = AM-m+AM-Gly), in plasma and pericardial fluid using our newly developed immunoradiometric assay in consecutive 67 patients undergoing coronary artery bypass graft surgery. Pericardial fluid and plasma cAMP, atrial natriuretic peptide and brain natriuretic peptide levels were also measured. The relationships between pericardial fluid AM levels and ventricular functions and other hormone levels were analysed. The level of each molecular form of AM in pericardial fluid was closely correlated with that of the other molecular forms of AM in the fluid. However, levels were not correlated with those in plasma. AM-T levels were slightly higher in pericardial fluid than in plasma (+72%; P |
| Databáze: | OpenAIRE |
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