Aminophosphonic Acids and Derivatives. Synthesis and Biological Applications
| Autor: | Fulvia Orsini, M. Sisti, Guido Sello |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Organic Chemistry Organophosphonates Enantioselective synthesis Antineoplastic Agents Stereoisomerism Biological activity Phosphate Antiviral Agents Biochemistry Phosphonate Chemical synthesis Anti-Bacterial Agents chemistry.chemical_compound Enzyme chemistry Drug Discovery Animals Humans Molecular Medicine Moiety Organic chemistry Enzyme Inhibitors Antibacterial agent |
| Zdroj: | ResearcherID |
| ISSN: | 0929-8673 |
| Popis: | In recent years, phosphonic acids and their derivatives have received increasing attention as analogues of a series of naturally occurring phosphates and as "bio-isosteric phosphorus analogues" of amino acids. Unlike a phosphate group, the phosphonate moiety is not readily hydrolyzed, in a biological environment, by the enzymes involved in the phosphate cleavage. This feature makes these compounds extremely useful in several applications, in metabolic regulation, in enhancement or inhibition studies, in the development of potential drugs against several metabolic disorders. The great potential of these compounds in biological applications resulted in an intense effort directed to the development of efficient synthetic methods for their preparation, with particular attention to stereoselective synthesis. The purpose of this review is to give an up-to-date account of the chemistry, the synthesis and the biological activity of aminophosphonic acids and their derivatives. |
| Databáze: | OpenAIRE |
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