Stimulation of a bulbospinal 5-HT pathway in the rat brain produces hyperglycaemia
| Autor: | L. R. Shian, M. T. Lin |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Blood Glucose
Male endocrine system medicine.medical_specialty Kainic acid Serotonin Physiology Efferent Clinical Biochemistry Central nervous system 5 7-Dihydroxytryptamine Glutamic Acid Stimulation Efferent Pathways chemistry.chemical_compound Glutamates Physiology (medical) Internal medicine Medicine Animals Medulla Medulla Oblongata Kainic Acid business.industry Adrenalectomy Rats Inbred Strains Anatomy Spinal cord Electric Stimulation Rats Kinetics medicine.anatomical_structure Endocrinology chemistry Spinal Cord Medulla oblongata business |
| Zdroj: | Pflugers Archiv : European journal of physiology. 416(5) |
| ISSN: | 0031-6768 |
| Popis: | The glucoregulatory role of spinally projecting serotonin (5-HT) neurones near the ventrolateral surface of the medulla oblongata was investigated by stimulating these nerve cells in normal rats and in rats with selective chemical ablation of 5-HT nerves in the spinal cord. Electrical stimulation of the lateral medulla produced hyperglycaemia in normal rats; the increase in blood glucose was proportional to the intensity and frequency of stimulation. Furthermore, microinjection of kainic acid or L-glutamate at the same sites also produced hyperglycaemia. This stimulation-induced hyperglycaemia was significantly reduced by spinal transection or adrenalectomy. Selective destruction of spinal 5-HT nerves produced by intraspinal injection of 5,7-dihydroxytryptamine also reduced the magnitude of the hyperglycaemia response to electrical stimulation of the lateral medulla. This indicates that stimulation of 5-HT nerve cells adjacent to the ventrolateral surface of the medulla oblongata and projecting to the spinal cord increases the adrenal-sympathetic efferent activity and leads to hyperglycaemia in rats. |
| Databáze: | OpenAIRE |
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