Determination of N-nitrosodimethylamine in artificial gastric juice by gas chromatography-mass spectrometry and by gas chromatography-thermal energy analysis
| Autor: | A. Tenfelde, D. van Doorn, R.C. Schothorst, Jan W. Dallinga, C.A.M. Krul, I.T.M. Vermeer, Edwin J.C. Moonen |
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| Přispěvatelé: | Gezondheidsrisico Analyse en Toxicologie, RS: NUTRIM School of Nutrition and Translational Research in Metabolism |
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Detection limit
Cancer Research Chromatography Gas Differential Thermal Analysis Gastric Juice Nitrosamines Chromatography Epidemiology Analyser Public Health Environmental and Occupational Health Mass spectrometry Models Biological Gas Chromatography-Mass Spectrometry chemistry.chemical_compound Oncology chemistry Nitrosamine N-Nitrosodimethylamine Reagent Carcinogens Humans Indicators and Reagents Gas chromatography Gas chromatography–mass spectrometry Digestive System |
| Zdroj: | European Journal of Cancer Prevention, 10, 265-268. LIPPINCOTT WILLIAMS & WILKINS |
| ISSN: | 0959-8278 |
| Popis: | Eur J Cancer Prev 2001 Jun;10(3):265-8 Related Articles, Books, LinkOut Determination of N-nitrosodimethylamine in artificial gastric juice by gas chromatography-mass spectrometry and by gas chromatography-thermal energy analysis.Dallinga JW, Krul CA, Tenfelde A, Moonen EJ, Vermeer IT, van Doorn D, Schothorst RC.Department of Health Risk Analysis and Toxicology, Faculty of Health Sciences, Maastricht University, The Netherlands. j.dallinga@grat.unimaas.nlThe thermal energy analyser (TEA) is considered to be the gold standard for the determination of nitrosamines. However, since many laboratories cannot justify the use of such a very specific detection system, alternative detection methods are useful. While standard gas chromatography (GC) detectors lack the selectivity of the TEA detector, mass spectrometry (MS) seems to be the method of choice to combine GC separation with mass selective detection. Moreover, the detection limits of the GC-MS assay in general use are about 4 times lower than those of the GC-TEA assay. A comparison of GC-MS and GC-TEA data on N-nitrosodimethylamine determinations showed a strong correlation between the two assays (R2 = 0.86), demonstrating the exchangeability of these methods. |
| Databáze: | OpenAIRE |
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