Social support and ovarian cancer incidence : a Swedish prospective population-based study
| Autor: | Ann Lalos, Annika Idahl, Andrea Hermansson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty endocrine system diseases The Interview Schedule for Social Interaction Carcinoma Ovarian Epithelial Cohort Studies 03 medical and health sciences Social support 0302 clinical medicine Social integration Risk Factors Internal medicine Serous ovarian cancer Medicine Humans Epithelial ovarian cancer Neoplasms Glandular and Epithelial Registries attachment Ovarian Neoplasms Sweden business.industry Incidence (epidemiology) Incidence Obstetrics and Gynecology Social Support social integration Public Health Global Health Social Medicine and Epidemiology Middle Aged social support medicine.disease female genital diseases and pregnancy complications Population based study Folkhälsovetenskap global hälsa socialmedicin och epidemiologi 030104 developmental biology ovarian cancer 030220 oncology & carcinogenesis Case-Control Studies Female Neoplasm Grading business Ovarian cancer serous ovarian cancer |
| Popis: | Objective: Low social support is associated with worse prognosis for epithelial ovarian cancer (EOC) patients. However, few studies have explored the relation between low social support and incidence of EOC. The aim of this prospective nested case-control study was to examine whether self-perceived low social support was associated with the incidence of EOC. Methods: The Swedish Cancer Registry was used to identify participants in the Vasterbotten Intervention Programme (VIP) comprising 58,000 women, who later developed EOC. Each case was matched to four cancer free controls. The VIP uses the Social Support questionnaire, a modified version of the validated questionnaire "The Interview Schedule for Social Interaction" (ISSI) measuring quantitative (AVSI) and qualitative (AVAT) aspects of social support. Results: The risk of EOC in relation to AVSI and AVAT was similar between the 239 cases and the 941 controls after adjustment for educational level, smoking, BMI, Cambridge Physical Activity Index and age (aOR 0.85, 95% CI 0.72-1.01 and aOR 0.54, 95% CI 0.16-1.81). Lagtime was found to have no impact. A decreased risk of serous ovarian cancer was seen in women with fewer persons available for informal socializing (aOR 0.75, 95% CI 0.59-0.95). Adjusted analyses showed non-significant odds ratios below 1.0 in the vast majority of histotypes. Conclusions: A general trend towards a decreased risk of ovarian cancer associated with low AVSI and AVAT was identified. Solely the serous subtype was significantly associated with low scores of AVSI. Prospective pathophysiological and epidemiological studies regarding social support are needed. |
| Databáze: | OpenAIRE |
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