Innate and adaptive functions of the CD1 pathway of antigen presentation
| Autor: | Se Ho Park, Jessica H. Roark, Ya Hui Chiu, Uma Kavita, Jayanthi Jayawardena, Albert Bendelac |
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| Rok vydání: | 1998 |
| Předmět: |
Antigen Presentation
Innate immune system Antigen processing T-Lymphocytes Immunology Antigen presentation Innate lymphoid cell Immunity Pattern recognition receptor Autoimmunity chemical and pharmacologic phenomena Biology Acquired immune system Cell biology Antigens CD1 Immune system Antigen Neoplasms Animals Humans Immunology and Allergy |
| Zdroj: | Seminars in Immunology. 10:391-398 |
| ISSN: | 1044-5323 |
| DOI: | 10.1006/smim.1998.0139 |
| Popis: | In the past few years, several studies have unravelled a novel pathway of antigen presentation to T cells of the mammalian immune system. The antigens are presented by CD1, which appears to have evolved to present glycolipid antigens to alphabeta T cells. CD1-restricted T cells are frequently autoreactive, and can promptly release key regulatory cytokines such as IL-4 and IFN-gamma. They have been implicated in a variety of autoimmune diseases including type I diabetes and lupus, in intracellular bacterial infections, and in tumor rejection. They are likely to be involved at the early, innate phase of these immune responses, providing a unique model to study the interface between the innate and adaptive immune systems. |
| Databáze: | OpenAIRE |
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