Solid and solution phase syntheses of the 2-cyanopyrrolidide DPP-IV inhibitor NVP-DPP728
| Autor: | Nicolas Willand, Jean-Claude Gesquiere, André Tartar, Michael Bryan Roe, Jurgen Joossens, D.Michael Evans |
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| Přispěvatelé: | Biostructures et Decouverte de Medicament, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Synthèse, structure et fonction des biomolécules (SSFB), Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Ferring research limited, Chilworth research center, Willand, Nicolas |
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
NVP-DPP728
010405 organic chemistry Chemistry Organic Chemistry [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences 010402 general chemistry cyanopyrrolidide 01 natural sciences Biochemistry Solution phase Combinatorial chemistry 0104 chemical sciences 3. Good health DPP-IV inhibitor [SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences Phase (matter) Drug Discovery |
| Zdroj: | Tetrahedron Tetrahedron, Elsevier, 2002, 58, pp.5741-5746. ⟨10.1016/S0040-4020(02)00536-7⟩ Tetrahedron, 2002, 58, pp.5741-5746. ⟨10.1016/S0040-4020(02)00536-7⟩ |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/S0040-4020(02)00536-7⟩ |
| Popis: | DPP-IV inhibitors have been suggested as potential new treatments for type-II diabetes and 2-cyanopyrrolidides have been reported as potent DPP-IV inhibitors. Alternative synthetic approaches to one such compound, NVP-DPP728, are investigated here. One strategy is based in solution phase and is amenable to scale-up. The other is based on solid phase and is appropriate for the rapid analoging of the structural series. |
| Databáze: | OpenAIRE |
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