Can tonsillectomy modify the innate and adaptive immunity pathways involved in IgA nephropathy?
| Autor: | Carola Licata, Filippo Mariano, Silvana Savoldi, Maria Elena Donadio, Piero Stratta, Alessandro Amore, Gianna Mazzucco, Marco Quaglia, Riccardo Magistroni, Roberta Camilla, Raffaella Cravero, Luca Vergano, Cristiana Rollino, Elisa Loiacono, Roberto Albera, Luisa Benozzi, Federica Chiale, Sara Ravera, Roberto Bergia, Rosanna Coppo, Licia Peruzzi, Giovanni Cancarini, Giulietta Beltrame, Alberto Boido, Stefano Cusinato |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male mucosal associated lymphoid tissue Immunoglobulin A Proteasome Endopeptidase Complex Adolescent adaptative immunity IgA nephropathy tonsillectomy innate immunity Gene Expression Adaptive Immunity Nephropathy Young Adult Immunity Humans Medicine RNA Messenger IgA nephropathy innate immunity tonsillectomy Innate immune system biology business.industry Toll-Like Receptors Galactose TLR9 Glomerulonephritis IGA Middle Aged Acquired immune system medicine.disease Healthy Volunteers Immunity Innate Toll-Like Receptor 2 Toll-Like Receptor 3 Toll-Like Receptor 4 IgA Nephropathy Cysteine Endopeptidases TLR2 Cross-Sectional Studies Advanced Oxidation Protein Products Nephrology Case-Control Studies Toll-Like Receptor 9 Immunology biology.protein TLR4 Female business |
| Zdroj: | Journal of Nephrology. 28:51-58 |
| ISSN: | 1724-6059 1121-8428 |
| Popis: | The benefits of tonsillectomy in IgA nephropathy (IgAN) are still debated. Tonsillectomy may remove pathogen sources and reduce the mucosal associated lymphoid tissue (MALT), limiting degalactosylated IgA1 (deGal-IgA1) production, which is considered to be the initiating pathogenetic event leading to IgA glomerular deposition. In the European network VALIGA, 62/1147 IgAN patients underwent tonsillectomy (TxIgAN). In a cross-sectional study 15 of these patients were tested and compared to 45 non-tonsillectomized IgAN (no-TxIgAN) and healthy controls (HC) regarding levels of deGal-IgA1, and markers of innate immunity and oxidative stress, including toll-like receptors (TLR)2, 3, 4 and 9 mRNAs, proteasome (PS) and immunoproteasome (iPS) mRNAs in peripheral blood mononuclear cells (PBMC), and advanced oxidation protein products (AOPP). Levels of deGal-IgA1 were lower in TxIgAN than in no-TxIgAN (p = 0.015), but higher than in HC (p = 0.003). TLR mRNAs were more expressed in TxIgAN than in HC (TLR4, p = 0.021; TLR9, p = 0.027), and higher in TxIgAN than in no-TxIgAN (p ≤ 0.001 for TLR2, 4, 9). A switch from PS to iPS was detected in PBMC of TxIgAN in comparison to HC and it was higher than in no-TxIgAN [large multifunctional peptidase (LMP)2/β1, p = 0.039; LPM7/β5, p < 0.0001]. The levels of AOPP were significantly higher in TxIgAN than HC (p < 0.001) and no-TxIgAN (p = 0.033). In conclusion, the activation of innate immunity via TLRs and ubiquitin–proteasome pathways and the pro-oxidative milieu were not affected by tonsillectomy, even though the levels of aberrantly galactosylated IgA1 were lower in patients with IgAN who had tonsillectomy. The residual hyperactivation of innate immunity in tonsillectomized patients may result from extra-tonsillar MALT. |
| Databáze: | OpenAIRE |
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