Evidence for differences in erythrocyte surface receptors for the malarial parasites, Plasmodium falciparum and Plasmodium knowlesi
| Autor: | J. D. Haynes, M H McGinniss, Louis H. Miller, F M McAuliffe, T Shiroishi, John R. Durocher |
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| Rok vydání: | 1977 |
| Předmět: |
Plasmodium
Erythrocytes Plasmodium falciparum Immunology Neuraminidase Sialidase parasitic diseases medicine Chymotrypsin Humans Immunology and Allergy Trypsin chemistry.chemical_classification biology Erythrocyte Membrane fungi Articles biology.organism_classification medicine.disease Virology Enzyme chemistry Plasmodium knowlesi biology.protein Duffy Blood-Group System Malaria medicine.drug |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| Popis: | Human erythrocytes lacking various blood group determinants were susceptible to invasion by Plasmodium falciparum including Duffy-negative erythrocytes that are refractory to invasion by Plasmodium knowlesi. Erythrocytes treated with trypsin or neuraminidase had reduced susceptibility of P. falciparum and normal susceptibility to P. knowlesi. Chymotrypsin treatment (0.1 mg/ml) blocked invasion only by P. knowlesi. The differential effect of enzymatic cleavage of determinats from the erythrocyte surface on invasion by these parasites suggests that P. falciparum and P. knowlesi interact with different determinants on the erythrocyte surface. |
| Databáze: | OpenAIRE |
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