A retrospective study comparing D1 limited lymph node dissection and D2 extended lymph node dissection for N3 gastric cancer
| Autor: | Xing Luo, Wei Tian, Honglin Hu, Yangke He, Liang Liang, Hao Liu, Min Wei, Gao-Ping Zhao, Liangfu Han, Ming-Xiu Zhou, Xinbao Hao, Li-Li Deng, Xueqiang Zhu, Ming Zeng, Jian-Ling Xia |
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| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
medicine.medical_specialty business.industry Cancer Retrospective cohort study D2 lymphadenectomy Dissection (medical) medicine.disease chemoradiotherapy surgery medicine.anatomical_structure Oncology medicine Original Article Radiology Nuclear Medicine and imaging Radiology Gastric cancer business Lymph node D1 lymphadenectomy |
| Zdroj: | Translational Cancer Research |
| ISSN: | 2219-6803 2218-676X |
| DOI: | 10.21037/tcr.2020.03.42 |
| Popis: | Background In countries in East Asia, the typical treatment for curable gastric cancer is gastrectomy with D2 lymphadenectomy. However, whether D2 lymphadenectomy is beneficial for high-risk N3 node disease remains controversial. We conducted a multi-institution retrospective study on patients with high-risk, locally advanced gastric cancer. To compare the rates of disease-free survival (DFS) and overall survival (OS) between radical D2-type gastric resection and lymphadenectomy and the more limited D1 type resection and lymphadenectomy. Methods From July 2010 to June 2015, 74 patients out of 949 who underwent curative-intent R0 surgery were selected in pairs to compare the survival outcomes between those who underwent radical D2 type (n=37) vs. the more limited D1 type (n=37) gastric resection and lymphadenectomy. Results The median DFS was 9.72 and 7.81 months for the D2 and D1 types, respectively (P=0.746), and the OS was 16.39 and 15.85 months for the D2 and D1 types, respectively (P=0.937). Conclusions No statistically significant differences in DFS and OS were noted between D1 and D2 procedures for those with N3 disease. Our results support the hypothesis that a novel multidisciplinary approach rather than a surgical approach alone is needed to improve the survival outcomes of high-risk patients with N3 gastric cancer. |
| Databáze: | OpenAIRE |
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