Progression of excess embryos to the blastocyst stage predicts pregnancy and implantation rates after intracytoplasmic sperm injection
| Autor: | Bulent Urman, Cengiz Alatas, Senai Aksoy, Aycan Sertac, Basak Balaban, Alp Nuhoglu |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Infertility
Adult Male animal structures Time Factors Pregnancy Rate medicine.medical_treatment Fertilization in Vitro Biology Intracytoplasmic sperm injection Male infertility Andrology Predictive Value of Tests Pregnancy medicine Humans Blastocyst Insemination Artificial Rehabilitation Obstetrics and Gynecology Embryo Cell Differentiation medicine.disease Embryo transfer Pregnancy rate medicine.anatomical_structure Reproductive Medicine embryonic structures Female |
| Zdroj: | Human reproduction (Oxford, England). 13(9) |
| ISSN: | 0268-1161 |
| Popis: | Excess embryos from patients undergoing intracytoplasmic sperm injection and embryo transfer for male infertility were cultured to determine the rate and timing of their progression to the blastocyst stage. In 194 embryo transfer cycles, four embryos with the morphologically best grading were transferred and at least two embryos were cultured. The cycles were classified as: group 1: no excess embryos reached blastocyst stage, group 2:50% of embryos reached blastocyst stage by days 4-5, group 3:50% of embryos reached the blastocyst stage by days 4-5, group 4:50% of the embryos reached blastocyst stage by days 6-7, group 5:50% of the embryos reached blastocyst stage by days 6-7. All groups were similar regarding female age, duration of infertility, and parameters of ovarian stimulation. In group 1, clinical pregnancy and implantation rates were 14 and 11% respectively, and were similar to those of group 4. In group 2, clinical pregnancy and implantation rates were 75 and 33%. Multiple implantations occurred in 81% of group 2 or 3 cycles, compared to none in group 1 cycles. The results suggest that the development potential of the embryo is intrinsic, and that embryos which carry a high potential for development yield a high clinical pregnancy rate and multiple implantations. |
| Databáze: | OpenAIRE |
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