Aging Linked to Type 2 Diabetes Increases Oxidative Stress and Chronic Inflammation
| Autor: | Martha A. Sánchez-Rodríguez, Rocío Ortiz, Juana Rosado-Pérez, Víctor Manuel Mendoza-Núñez, Edelmiro Santiago-Osorio, Rosa Elba Galván-Duarte |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Aging medicine.medical_specialty Type 2 diabetes Risk Factors Hyperinsulinism Internal medicine Diabetes mellitus medicine Humans Risk factor Aged Inflammation Metabolic Syndrome chemistry.chemical_classification biology Interleukin-6 Tumor Necrosis Factor-alpha business.industry Glutathione peroxidase C-reactive protein Case-control study Odds ratio Middle Aged medicine.disease Oxidative Stress C-Reactive Protein Endocrinology Diabetes Mellitus Type 2 chemistry Case-Control Studies biology.protein Female Geriatrics and Gerontology business Biomarkers |
| Zdroj: | Rejuvenation Research. 14:25-31 |
| ISSN: | 1557-8577 1549-1684 |
| DOI: | 10.1089/rej.2010.1054 |
| Popis: | Oxidative stress (OxS) and inflammation are physiopathological mechanisms related to diabetes and aging. We evaluated the additive effect of diabetes and aging on OxS and inflammation in a cross-sectional comparative study of 228 subjects: (1) 56 healthy adults (mean age, 47 ± 7 years); (2) 60 diabetic adults (mean age, 52 ± 6 years); (3) 40 healthy elderly adults (mean age, 67 ± 7 years); and (4) 72 diabetic elderly adults (mean age, 68 ± 7 years). We measured levels of glycosylated hemoglobin (HbA1c), plasma lipid peroxides, superoxide dismutase, glutathione peroxidase, total antioxidants, and tumor necrosis factor-alpha (TNF-α). The results indicate that diabetes is a risk factor for subjects with high serum levels of TNF-α (odds ratio [OR] = 12.1; 95% confidence interval [95% CI], 5.0-28; p |
| Databáze: | OpenAIRE |
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