Plasma Cell Leukemia Presenting with Diplopia due to Unilateral Abducens Paralysis and Complex Chromosomal Abnormalities
| Autor: | Tohru Ogihara, Aya Nakaya, Norihiro Awaya |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Pathology medicine.medical_specialty Sphenoid Sinus Chromosomal translocation Translocation Genetic Leukemia Plasma Cell Fatal Outcome Diplopia Internal Medicine medicine Paralysis Humans Sinus (anatomy) Aged Chromosome Aberrations Chromosomes Human Pair 14 Plasma cell leukemia medicine.diagnostic_test business.industry Chromosomes Human Pair 11 Cranial nerves Magnetic resonance imaging General Medicine medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Liver Disease Progression medicine.symptom Tomography X-Ray Computed business Abducens Nerve Diseases |
| Zdroj: | Internal Medicine. 45:637-640 |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.45.1545 |
| Popis: | Involvement of cranial nerves is rare in plasma cell leukemia (PCL). Here, we report a case of PCL presenting with unilateral abducens paralysis. Cranial magnetic resonance imaging (MRI) disclosed a mass in the sphenoid sinus. Although the patient showed an initial response to chemotherapy, he died of disease progression 5 months later. Cytogenetic analysis showed translocation of chromosomes 11 and 14, t(11;14) (q13;q32), with additional complex abnormalities. This case implies an association between clinical manifestations and chromosomal abnormalities. |
| Databáze: | OpenAIRE |
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