Vitamin K status is not associated with cognitive decline in middle aged adults
| Autor: | M. den Heijer, Cees Vermeer, Renate Marie Louise Zwijsen, E. G. H. M. van den Heuvel, N.M. van Schoor, Hannie C. Comijs |
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| Přispěvatelé: | Epidemiology and Data Science, Internal medicine, Psychiatry, EMGO - Mental health, Biochemie, RS: CARIM - R1 - Thrombosis and haemostasis |
| Rok vydání: | 2015 |
| Předmět: |
Male
Gerontology Longitudinal study Vitamin K speed of information processing Nutritional Status Cognitive decline Medicine (miscellaneous) vitamin K status Gee desphopho-uncarboxylated matrix Gla-protein Cognition Matrix gla protein Vitamin K deficiency Vitamin D and neurology Humans Medicine Longitudinal Studies Vitamin D Generalized estimating equation Extracellular Matrix Proteins Nutrition and Dietetics biology business.industry Calcium-Binding Proteins Vitamins Middle Aged medicine.disease biology.protein Female Vitamin K Deficiency Geriatrics and Gerontology Cognition Disorders business Demography |
| Zdroj: | Journal of Nutrition Health and Aging, 19(9), 908-912. Springer Paris Journal of Nutrition Health & Aging, 19(9), 908-912. Springer van den Heuvel, E G H M, van Schoor, N M, Vermeer, C, Zwijsen, R M L, den Heijer, M & Comijs, H C 2015, ' Vitamin K status is not associated with cognitive decline in middle aged adults ', Journal of Nutrition Health and Aging, vol. 19, no. 9, pp. 908-912 . https://doi.org/10.1007/s12603-015-0579-8 |
| ISSN: | 1760-4788 1279-7707 |
| DOI: | 10.1007/s12603-015-0579-8 |
| Popis: | The aim of this study was to examine the association between dephospho-uncarboxylated matrix Gla protein (dp-ucMGP), an indicator of vitamin K status, and cognitive decline, and the modifying role of 25(OH)D. Longitudinal study with six years follow-up. Community based. 599 participants of the Longitudinal Aging Study Amsterdam (aged 55-65 years). Information processing speed and a composite Z-score by combining three domains of cognition reflecting general cognitive functioning. Generalized estimating equations (GEE) showed no significant associations between dp-ucMGP and decline in general cognitive functioning. Vitamin D modified the association between dp-ucMGP and speed of information processing (p 50 nmol/l, the highest tertile of dp-ucMGP (> 406 pmol/l), which corresponds to lower vitamin K levels, was associated with 1.5 higher score on information processing speed (p=0.023) as compared to the lowest tertile of dp-ucMGP. In contrast to our hypothesis, a suboptimal vitamin K was not associated with cognitive decline in middle-aged adults. |
| Databáze: | OpenAIRE |
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