[Biochemical markers predicting response to radiation- and radiochemo-therapy in cancer patients]
Autor: | S D, Ivanov |
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Rok vydání: | 2013 |
Předmět: |
Microarray
medicine.medical_treatment Radiogenomics Single-nucleotide polymorphism Apoptosis General Medicine Computational biology Biology Prognosis Tumor tissue Genome Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology Radiation therapy Gene Expression Regulation Neoplastic Treatment Outcome Predictive Value of Tests Neoplasms medicine Biomarkers Tumor Humans DNA microarray Biochemical markers Biomarkers |
Zdroj: | Biomeditsinskaia khimiia. 58(6) |
ISSN: | 2310-6972 |
Popis: | In last years there is increasing interest in radiogenomics and the characterization of DNA array molecular profiles that can predict tumor and no tumor tissues radioresponse. Ongoing studies carried out worldwide in the banking of tumor and no tumor samples give evidence that perspective markers for response prediction in individual patient to intended radiation therapy can be some apoptotic indexes, spectrum a number of specific proteins, and DNA-based microarray molecular profiling analysis as well determination of single nucleotide polymorphisms in genome of the patients. So far there are only a few robust reports of molecular markers predicting tumor and no tumor tissues response to radiation. The results of new studies, which in future should be validated in larger definitive trials, are likely to see in nearest years. It is needed to determine technologies of methods and to define more precisely areas of its applications. |
Databáze: | OpenAIRE |
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