Cardiovascular disease risk is only elevated in hypertensive, formerly preeclamptic women
Autor: | Marc E. A. Spaanderman, M. J. van der Vlugt, Wieteke M. Heidema, Chahinda Ghossein-Doha, Ralph R. Scholten, Smj van Kuijk, A.P.J. van Dijk, N. M. Breetveld |
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Přispěvatelé: | RS: CAPHRI School for Public Health and Primary Care, RS: CAPHRI - R5 - Optimising Patient Care, RS: GROW - Developmental Biology, Obstetrie & Gynaecologie, MUMC+: MA Arts Assistenten Obstetrie Gynaecologie (9), Epidemiologie, RS: GROW - R4 - Reproductive and Perinatal Medicine |
Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: |
0301 basic medicine
Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] Blood Pressure BLOOD-PRESSURE Body Mass Index 0302 clinical medicine Pre-Eclampsia Risk Factors FRAMINGHAM HISTORY Netherlands education.field_of_study Framingham Risk Score medicine.diagnostic_test PRIMARY-CARE Obstetrics and Gynecology Lipids PREGNANCY Cardiovascular Diseases PRACTICE GUIDELINES Female Adult medicine.medical_specialty hypertension Population Pregnancy Complications Cardiovascular 030209 endocrinology & metabolism HEART-ASSOCIATION Tertiary referral hospital Risk Assessment metabolic syndrome Preeclampsia preeclampsia 03 medical and health sciences Internal medicine medicine MANAGEMENT Humans education METAANALYSIS Pregnancy business.industry Other Research Radboud Institute for Health Sciences [Radboudumc 0] medicine.disease Cardiovascular risk Blood pressure 030104 developmental biology Case-Control Studies Physical therapy Disease risk ARTERIAL-HYPERTENSION Framingham risk score Metabolic syndrome Lipid profile business |
Zdroj: | BJOG : an International Journal of Obstetrics and Gynaecology, 122, 8, pp. 1092-100 Bjog-an International Journal of Obstetrics and Gynaecology, 122(8), 1092-1100. Wiley BJOG : an International Journal of Obstetrics and Gynaecology, 122, 1092-100 |
ISSN: | 1470-0328 |
DOI: | 10.1111/1471-0528.13057 |
Popis: | Contains fulltext : 154708.pdf (Publisher’s version ) (Closed access) OBJECTIVE: To analyse the predicted 10- and 30-year risk scores for cardiovascular disease (CVD) in patients who experienced preeclampsia (PE) 5-10 years previously compared with healthy parous controls. DESIGN: Observational study. SETTING: Tertiary referral hospital in the Netherlands. POPULATION: One hundred and fifteen patients with a history of PE and 50 controls. PE patients were categorised into two groups, hypertensive (n = 21) and normotensive (n = 94), based on use of antihypertensive medication, and next categorised into subgroups based on the onset of PE: early-onset PE (n = 39) and late-onset PE (n = 76). METHODS: All participants underwent cardiovascular risk screening 5-10 years after index pregnancy. We measured body mass, height and blood pressure. Blood was analysed for fasting glucose, insulin and lipid levels. All participants completed a validated questionnaire. The 10- and 30-year Framingham risk scores were calculated and compared. MAIN OUTCOME MEASURES: Estimated Framingham 10- and 30-year risk scores for CVD. RESULTS: The overall 10- and 30-year CVD median risks weighing subjects' lipids were comparable between formerly PE women and controls; 1.6 versus 1.5% (P = 0.22) and 9.0 versus 9.0% (P = 0.49), respectively. However, hypertensive formerly PE women have twice the CVD risk as normotensive formerly PE women: 10- and 30-year CVD median risks were 3.1 versus 1.5% (P < 0.01) and 19.0% versus 8.0% (P < 0.01), respectively. Risk estimates based on BMI rather than lipid profile show comparable results. Early-onset PE clustered more often in the hypertensive formerly PE group and showed significantly higher 10- and 30-year CVD risk estimates based on lipids compared with the late-onset PE group: 1.7 versus 1.3% (P < 0.05) and 10.0 versus 7.0% (P < 0.05), respectively. CONCLUSIONS: Women who are hypertensive after preeclampsia, have a twofold risk of developing CVD in the next 10-30 years. Formerly PE women who are normotensive in the first 10 years after their preeclamptic pregnancy have a comparable future cardiovascular risk to healthy controls. |
Databáze: | OpenAIRE |
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