Cardiovascular disease risk is only elevated in hypertensive, formerly preeclamptic women

Autor: Marc E. A. Spaanderman, M. J. van der Vlugt, Wieteke M. Heidema, Chahinda Ghossein-Doha, Ralph R. Scholten, Smj van Kuijk, A.P.J. van Dijk, N. M. Breetveld
Přispěvatelé: RS: CAPHRI School for Public Health and Primary Care, RS: CAPHRI - R5 - Optimising Patient Care, RS: GROW - Developmental Biology, Obstetrie & Gynaecologie, MUMC+: MA Arts Assistenten Obstetrie Gynaecologie (9), Epidemiologie, RS: GROW - R4 - Reproductive and Perinatal Medicine
Jazyk: angličtina
Rok vydání: 2015
Předmět:
0301 basic medicine
Vascular damage Radboud Institute for Health Sciences [Radboudumc 16]
Blood Pressure
BLOOD-PRESSURE
Body Mass Index
0302 clinical medicine
Pre-Eclampsia
Risk Factors
FRAMINGHAM
HISTORY
Netherlands
education.field_of_study
Framingham Risk Score
medicine.diagnostic_test
PRIMARY-CARE
Obstetrics and Gynecology
Lipids
PREGNANCY
Cardiovascular Diseases
PRACTICE GUIDELINES
Female
Adult
medicine.medical_specialty
hypertension
Population
Pregnancy Complications
Cardiovascular

030209 endocrinology & metabolism
HEART-ASSOCIATION
Tertiary referral hospital
Risk Assessment
metabolic syndrome
Preeclampsia
preeclampsia
03 medical and health sciences
Internal medicine
medicine
MANAGEMENT
Humans
education
METAANALYSIS
Pregnancy
business.industry
Other Research Radboud Institute for Health Sciences [Radboudumc 0]
medicine.disease
Cardiovascular risk
Blood pressure
030104 developmental biology
Case-Control Studies
Physical therapy
Disease risk
ARTERIAL-HYPERTENSION
Framingham risk score
Metabolic syndrome
Lipid profile
business
Zdroj: BJOG : an International Journal of Obstetrics and Gynaecology, 122, 8, pp. 1092-100
Bjog-an International Journal of Obstetrics and Gynaecology, 122(8), 1092-1100. Wiley
BJOG : an International Journal of Obstetrics and Gynaecology, 122, 1092-100
ISSN: 1470-0328
DOI: 10.1111/1471-0528.13057
Popis: Contains fulltext : 154708.pdf (Publisher’s version ) (Closed access) OBJECTIVE: To analyse the predicted 10- and 30-year risk scores for cardiovascular disease (CVD) in patients who experienced preeclampsia (PE) 5-10 years previously compared with healthy parous controls. DESIGN: Observational study. SETTING: Tertiary referral hospital in the Netherlands. POPULATION: One hundred and fifteen patients with a history of PE and 50 controls. PE patients were categorised into two groups, hypertensive (n = 21) and normotensive (n = 94), based on use of antihypertensive medication, and next categorised into subgroups based on the onset of PE: early-onset PE (n = 39) and late-onset PE (n = 76). METHODS: All participants underwent cardiovascular risk screening 5-10 years after index pregnancy. We measured body mass, height and blood pressure. Blood was analysed for fasting glucose, insulin and lipid levels. All participants completed a validated questionnaire. The 10- and 30-year Framingham risk scores were calculated and compared. MAIN OUTCOME MEASURES: Estimated Framingham 10- and 30-year risk scores for CVD. RESULTS: The overall 10- and 30-year CVD median risks weighing subjects' lipids were comparable between formerly PE women and controls; 1.6 versus 1.5% (P = 0.22) and 9.0 versus 9.0% (P = 0.49), respectively. However, hypertensive formerly PE women have twice the CVD risk as normotensive formerly PE women: 10- and 30-year CVD median risks were 3.1 versus 1.5% (P < 0.01) and 19.0% versus 8.0% (P < 0.01), respectively. Risk estimates based on BMI rather than lipid profile show comparable results. Early-onset PE clustered more often in the hypertensive formerly PE group and showed significantly higher 10- and 30-year CVD risk estimates based on lipids compared with the late-onset PE group: 1.7 versus 1.3% (P < 0.05) and 10.0 versus 7.0% (P < 0.05), respectively. CONCLUSIONS: Women who are hypertensive after preeclampsia, have a twofold risk of developing CVD in the next 10-30 years. Formerly PE women who are normotensive in the first 10 years after their preeclamptic pregnancy have a comparable future cardiovascular risk to healthy controls.
Databáze: OpenAIRE