A spontaneous thymic carcinosarcoma in a young Sprague Dawley rat
| Autor: | Shino Ito, Kei Kijima, Ayako Shiraki, Miki Suehiro-Narita, Aisuke Nii |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Malignant Thymoma
Pathology medicine.medical_specialty Sprague Dawley rat Cartilage carcinosarcoma Case Report Nodule (medicine) Biology Toxicology medicine.disease Mesenchymal chondrosarcoma Pathology and Forensic Medicine Basophilic medicine.anatomical_structure thymus Cytoplasm Carcinosarcoma Eosinophilic medicine medicine.symptom spontaneous |
| Zdroj: | Journal of Toxicologic Pathology |
| ISSN: | 1881-915X 0914-9198 |
| DOI: | 10.1293/tox.2020-0073 |
| Popis: | We encountered a case of spontaneous thymic carcinosarcoma in a young Crl:CD (Sprague Dawley) rat. Grossly, a white multinodular mass replaced the thymus in the thoracic cavity. Histologically, multiple nodules were separated by fibrous stroma, and each nodule included isolated regions that were composed of epithelial or non-epithelial tumor cells. The epithelial tumor cells were relatively large and round to polygonal cells with large nuclei and weakly eosinophilic cytoplasm. These cells were cytokeratin-positive and vimentin-negative. These cells infiltrated the lungs. The non-epithelial tumor cells were poorly differentiated, small, round to spindle-shaped cells with small nuclei and basophilic cytoplasm. These cells were vimentin-positive and mostly cytokeratin-negative. Many islands of cartilage were observed near non-epithelial cells. Based on these findings, the tumor was diagnosed as a primary thymic carcinosarcoma consisting of a malignant thymoma composed of epithelial tumor cells and a mesenchymal chondrosarcoma composed of non-epithelial tumor cells. |
| Databáze: | OpenAIRE |
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