Extreme Neuroplasticity of Hippocampal CA1 Pyramidal Neurons in Hibernating Mammalian Species
| Autor: | John M. Horowitz, Barbara A Horwitz |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Hibernation hippocampus Mini Review neuroplasticity Neuroscience (miscellaneous) Hippocampus Stimulation Hippocampal formation Biology Basic Behavioral and Social Science lcsh:RC321-571 lcsh:QM1-695 Arousal memory 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine pyramidal cells Neuroplasticity Behavioral and Social Science Biological neural network hibernation lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry pyramidal cells (PC) musculoskeletal neural and ocular physiology Neurosciences Long-term potentiation lcsh:Human anatomy Brain Disorders 030104 developmental biology Mental Health nervous system Neurological Anatomy LTP Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Neuroanatomy Frontiers in Neuroanatomy, Vol 13 (2019) |
| ISSN: | 1662-5129 |
| Popis: | In awake and behaving mammals (with core and brain temperatures at ~37 degrees C), hippocampal neurons have anatomical and physiological properties that support formation of memories. However, studies of hibernating mammalian species suggest that as hippocampal temperature falls to values below ~10oC, CA1 neurons lose their ability to generate long term potentiation (LTP), a basic form of neuroplasticity. That is, the persistent increase in CA3-CA1 synaptic strength following high-frequency stimulation of CA3 fibers (the hallmark of LTP generation at 37oC) is no longer observed at low brain temperatures although the neurons retain their ability to generate action potentials. In this review, we examine the relationship of LTP to recently observed CA1 structural changes in pyramidal neurons during the hibernation cycle, including the reversible formation of hyperphosphorylated tau. While CA1 neurons appear to be stripped of their ability to generate LTP at low temperatures, their ability to still generate action potentials is consistent with the longstanding proposal that they have projections to neural circuits controlling arousal state throughout the hibernation cycle. Recent anatomical studies significantly refine and extend previous studies of cellular plasticity and arousal state and suggest experiments that further delineate the mechanisms underlying the extreme plasticity of these CA1 neurons. |
| Databáze: | OpenAIRE |
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