Geographical differences in tonsillar carriage rates of Fusobacterium necrophorum - A cross-sectional study in Sweden and Zambia
| Autor: | Karin Holm, Ellen Brorson, Åsa Johansson, Lisa Wasserstrom, David Nygren, Michael Musonda |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Adolescent Cross-sectional study ved/biology.organism_classification_rank.species Zambia Microbiology 03 medical and health sciences Young Adult Fusobacterium necrophorum Medicine Humans Young adult 030304 developmental biology Sweden 0303 health sciences Geography 030306 microbiology ved/biology business.industry Age Factors Tonsillitis Infectious Diseases Carriage Cross-Sectional Studies Fusobacterium Infections Age distribution Female business Demography |
| Zdroj: | Anaerobe. 69 |
| ISSN: | 1095-8274 |
| Popis: | While Fusobacterium necrophorum historically has been considered normal tonsillar flora, recent studies from Europe and the US have suggested that carriage occur transiently in adolescence and young adulthood. However, no studies originating from Africa exist. In this cross-sectional study of tonsillar carriage of F. necrophorum, we aimed to investigate geographical differences in tonsillar carriage rates of F. necrophorum in healthy participants aged 15-25 years in Sweden and Zambia and further investigate the age distribution of tonsillar carriage in Zambia. Specimens were obtained by tonsillar swabs and analyzed with real-time PCR for F. necrophorum. In participants aged 15-25 years, tonsillar carriage was more common in Sweden 21/100 (21%) than in Zambia 6/192 (3%), p 0.001. In Zambian participants aged above 25 years tonsillar carriage was rare 1/76 (1%). In conclusion, the high rate of tonsillar carriage in participants aged 15-25 years in Sweden has implications on the interpretation of tonsillar findings in patients with pharyngotonsillitis. Interestingly, a geographical difference was found with tonsillar carriage rarely identified in Zambia. |
| Databáze: | OpenAIRE |
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