Heterogeneity in Colorectal Cancer: A Challenge for Personalized Medicine?

Autor: Giulia De Maio, Paola Ulivi, Chiara Molinari, Alessandro Passardi, Laura Matteucci, Giorgia Marisi
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Oncology
medicine.medical_specialty
Response to therapy
Colorectal cancer
colorectal cancer
Review
Molecular heterogeneity
Catalysis
Metastasis
Inorganic Chemistry
lcsh:Chemistry
03 medical and health sciences
Genetic Heterogeneity
0302 clinical medicine
response to therapy
Internal medicine
medicine
Biomarkers
Tumor
metastasis
Humans
Physical and Theoretical Chemistry
Liquid biopsy
cfDNA
Neoplasm Metastasis
Precision Medicine
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
Neoplasm Staging
Biological Variation
Individual
liquid biopsy
business.industry
Organic Chemistry
General Medicine
medicine.disease
Tumor tissue
Minimal residual disease
Computer Science Applications
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
Molecular Diagnostic Techniques
030220 oncology & carcinogenesis
Personalized medicine
tumor tissue
heterogeneity
business
Colorectal Neoplasms
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 19, Iss 12, p 3733 (2018)
ISSN: 1422-0067
Popis: High inter-patient variability and high spatial heterogeneity are features of colorectal cancer (CRC). This may influence the molecular characterization of tumor tissue, now mandatory for patients with metastatic CRC who are candidates for treatment with an anti-EGFR mAb, as false-negative results can occur, leading to non optimal therapy. Moreover, temporal molecular heterogeneity during treatment is known to influence the response to therapy and prognosis. We present a literature overview of advances made in characterizing molecular heterogeneity in CRC, underlining that the analysis of liquid biopsy could represent an efficient non-invasive tool to overcome the problem. We believe that understanding CRC heterogeneity is fundamental for a more accurate diagnosis, for selecting the best targets to ensure prolonged antitumor response, and for monitoring minimal residual disease and the onset of resistance to therapy, all essential components of successful personalized treatment.
Databáze: OpenAIRE
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