Osteoformin Accelerates Fresh Fracture Healing in Rats
| Autor: | William L. Buford, Elgene G. Mainous, Lian Xiang Bi, Ya Ping Zeng |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Bone Regeneration Fracture site Bone healing law.invention Intramedullary rod Fractures Bone Electricity In vivo law medicine Animals Femur Fracture Healing Osteoblasts business.industry Phosphate buffered saline Osteoblast Femoral fracture medicine.disease Osteoformin Rats Surgery Radiography medicine.anatomical_structure Otorhinolaryngology Anesthesia Oral Surgery Peptides business |
| Zdroj: | Journal of Oral and Maxillofacial Surgery. 65:2470-2474 |
| ISSN: | 0278-2391 |
| DOI: | 10.1016/j.joms.2007.06.630 |
| Popis: | Purpose Negatively charged resins have been shown to stimulate bone repair. In previous studies, the negatively charged polypeptide polyaspartate, which has been named Osteoformin, has been shown to stimulate osteoblast differentiation in vitro. The objective of the current study was to investigate the potential effect of Osteoformin on experimental femoral fracture healing in vivo. Materials and Methods Thirty-six male Sprague-Dawley rats were used. The femurs of anesthetized rats were stabilized with intramedullary pins and subjected to closed midshaft transverse facture by bending to failure. In experimental rats, fracture sites were injected with 100 μg of Osteoformin dissolved in 0.1 mL phosphate buffered saline (PBS) at day 1 and day 7 after surgery; in controls groups, fracture sites received 0.1 mL PBS at the intervals indicated above. Between 2 and 4 weeks after fracture, the animals were sacrificed and the healing femurs were removed for radiographic and histologic analysis. Results Osteoformin decreased the healing time of fresh fractures in rats, as indicated by histologic and radiographic assessments. Conclusion The results of this study show that Osteoformin improves femoral fracture healing in rats. |
| Databáze: | OpenAIRE |
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