Metabolism of 1,3-dibromopropane
| Autor: | Sybil P. James, M.A. Pue, D.H. Richards |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
medicine.medical_specialty
Metabolite Urine 1 3-Dibromopropane Toxicology Propane chemistry.chemical_compound Oral administration Internal medicine Hepatic glutathione medicine Animals Bile Carbon Radioisotopes Biotransformation Chromatography General Medicine Glutathione Metabolism Hydrocarbons Brominated Rats Endocrinology Liver chemistry Cysteine |
| Zdroj: | Toxicology Letters. 8:7-15 |
| ISSN: | 0378-4274 |
| DOI: | 10.1016/0378-4274(81)90130-2 |
| Popis: | Oral administration of 1,3-dibromopropane (2 mmol/kg) to rats resulted in a marked decrease in the level of hepatic glutathione (GSH). Sulphur-containing [14C]-metabolites were excreted in the bile of rats dose with 1,3-bromo[14C]propane and were subjected to enterohepatic cycling. After an oral dose of 1,3-dibromo[14C]propane, peak levels of radioactivity were rapidly attained in the blood and were maintained for several hours; approximately equal amounts of radioactive material were excreted in urine and expired air. Several radioactive metabolites were excreted in urine; a major metabolite was N-acetyl-S-[1-bromo-3-propyl]-cysteine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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