A novel 99mTc labelling strategy for the development of silica based particles for medical applications
| Autor: | Michel A. Wuillemin, Michael J. Reber, Henrik Braband, Roger Alberto, Thomas Fox, Wanda T. Stuber, Dominik Brühwiler |
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| Přispěvatelé: | University of Zurich, Braband, Henrik |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Models
Molecular 10120 Department of Chemistry Materials science Mesoporous Alkenes Inorganic Chemistry Reaction rate chemistry.chemical_compound Labelling 540 Chemistry Humans Organic chemistry Radioimaging Norbornene Cycloaddition Reaction 1604 Inorganic Chemistry Technetium Stereoisomerism Silica Organotechnetium Compounds Mesoporous silica Silicon Dioxide Norbornanes Combinatorial chemistry 540: Chemie 610: Medizin und Gesundheit chemistry Radiopharmaceuticals Mesoporous material |
| Popis: | The reaction of high-valent fac-{(99m)TcO3}(+) complexes with alkenes ((3 + 2)-cycloaddition) has been used to develop a novel labelling procedure for silica based particles. This strategy can help to gain more detailed in vivo data of mesoporous silica by non-invasive radioimaging in the future. By applying norbornene as a coupling unit the (3 + 2)-cycloaddition reaction proceeds stereoselectively and with high reaction rates. |
| Databáze: | OpenAIRE |
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