Effects of ABO Matching of Platelet Transfusions in Critically Ill Children
| Autor: | Jhuma Sankar, Anil Sapru, Laura Watkins, Jon Lillie, Anna Camporesi, Ofer Schiller, Andrew Meyer, Oliver Karam, ELENA CAVAZZONI, Fabrizio Chiusolo, Antonio Perez Ferrer, James Killinger, Kenneth Remy, Jesus Lopez-Herce, Mara L Leimanis Laurens, Edward Vincent S. Faustino, Kevin Kuo, Hari Krishnan Kanthimathinathan, Srinivas Murthy, Mark Peters, Arun Saini, Shubhi Kaushik, Andy Wen, Angela Aramburo |
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| Přispěvatelé: | Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Grazioli, Serge, Pediatric Surgery |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_treatment Critical Care and Intensive Care Medicine Platelet Count/statistics & numerical data Primary outcome Interquartile range hemic and lymphatic diseases and the P3T Investigators Platelet Prospective Studies Prospective cohort study Child Pediatric ddc:618 Hematology Platelet Transfusion/adverse effects/methods Intensive Care Units Blood Grouping and Crossmatching/methods Blood Child Preschool Female medicine.medical_specialty congenital hereditary and neonatal diseases and abnormalities Adolescent pediatrics Pediatric Critical Care Blood Research Network (BloodNet) Critical Illness Platelet Transfusion Nursing Intensive Care Units Pediatric Paediatrics and Reproductive Medicine Clinical Research ABO blood group system Internal medicine parasitic diseases medicine Humans Pediatric/statistics & numerical data Preschool ABO compatibility Mechanical ventilation business.industry Critically ill Platelet Count Infant Newborn Infant Transfusion Reaction Newborn Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network biological factors Platelet transfusion Blood Grouping and Crossmatching P3T Investigators Pediatrics Perinatology and Child Health Transfusion Reaction/epidemiology sense organs business |
| Zdroj: | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 20(2), e61-e69. LIPPINCOTT WILLIAMS & WILKINS Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, vol 20, iss 2 Pediatric Critical Care Medicine, Vol. 20, No 2 (2019) pp. e61-e69 Pediatric Critical Care Medicine, 20(2), E61-E69. Lippincott Williams & Wilkins |
| ISSN: | 1529-7535 |
| DOI: | 10.1097/pcc.0000000000001779 |
| Popis: | OBJECTIVES: To determine if transfusing ABO compatible platelets has a greater effect on incremental change in platelet count as compared to ABO incompatible platelets in critically ill children.DESIGN: Secondary analysis of a prospective, observational study. Transfusions were classified as either ABO compatible, major incompatibility, or minor incompatibility. The primary outcome was the incremental change in platelet count. Transfusion reactions were analyzed as a secondary outcome.SETTING: Eighty-two PICUs in 16 countries.PATIENTS: Children (3 d to 16 yr old) were enrolled if they received a platelet transfusion during one of the predefined screening weeks.INTERVENTIONS: None.MEASUREMENTS AND MAIN RESULTS: Five-hundred three children were enrolled and had complete ABO information for both donor and recipient, as well as laboratory data. Three-hundred forty-two (68%) received ABO-identical platelets, 133 (26%) received platelets with major incompatibility, and 28 (6%) received platelets with minor incompatibility. Age, weight, proportion with mechanical ventilation or underlying oncologic diagnosis did not differ between the groups. After adjustment for transfusion dose, there was no difference in the incremental change in platelet count between the groups; the median (interquartile range) change for ABO-identical transfusions was 28 × 10 cells/L (8-68 × 10 cells/L), for transfusions with major incompatibility 26 × 10 cells/L (7-74 × 10 cells/L), and for transfusions with minor incompatibility 54 × 10 cells/L (14-81 × 10 cells/L) (p = 0.37). No differences in count increment between the groups were noted for bleeding (p = 0.92) and nonbleeding patients (p = 0.29). There were also no differences observed between the groups for any transfusion reaction (p = 0.07).CONCLUSIONS: No differences were seen in the incremental change in platelet count nor in transfusion reactions when comparing major ABO incompatible platelet transfusions with ABO compatible transfusions in a large study of critically ill children. Studies in larger, prospectively enrolled cohorts should be performed to validate whether ABO matching for platelet transfusions in critically ill children is necessary. |
| Databáze: | OpenAIRE |
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