Isolation and Cytotoxicity of Two New Flavonoids from Chrysosplenium grayanum and Related Flavonols
| Autor: | Hua Bai, Mineo Shimizu, Shougo Kuze, Naokata Morita, Yusuke Ito, Toshimitsu Hayashi, Munehisa Arisawa |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Stereochemistry
Flavonoid Pharmaceutical Science Pharmacognosy Analytical Chemistry Retusin (flavonol) chemistry.chemical_compound Flavonols Drug Discovery Tumor Cells Cultured Humans Cytotoxicity Flavonoids Pharmacology chemistry.chemical_classification Molecular Structure biology Organic Chemistry Saxifragaceae biology.organism_classification Antineoplastic Agents Phytogenic In vitro Chrysosplenium grayanum Complementary and alternative medicine chemistry Molecular Medicine Drug Screening Assays Antitumor Drugs Chinese Herbal |
| Zdroj: | Journal of Natural Products. 54:898-901 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | In view of the observation that a CHCl3-soluble fraction of the MeOH extract of Chrysosplenium grayanum has shown cytotoxic activity in the KB cell in vitro system, the fraction has been further fractionated to furnish five known flavonoids (chrysosplenols B, D, and E, retusin, and brickellin), 3,5-dihydroxy-4-methoxybenzoic acid methyl ester, and two new flavonoids named chrysosplenols F [1] and G [2]. The structures of the new flavonoids have been elucidated to be 5,4',5'-trihydroxy-3,7,2'-trimethoxyflavone [1] and 5,5'-dihydroxy-3,7,2',4'-tetramethoxyflavone [2] on the basis of spectral data. Certain of the isolated compounds and related flavonol aglycones showed marginal activities against KB cells in vitro. |
| Databáze: | OpenAIRE |
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