Monitoring of a Hot Melt Coating Process via a Novel Multipoint Near-Infrared Spectrometer
| Autor: | Peter Kerschhaggl, Otto Scheibelhofer, Roland Hohl, Detlev Haack, Elena Stocker, Sharareh Salar Behzadi, Stephan Sacher, Andreas Zimmer, Dirk Lochmann, Kai Koch |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Optical fiber
Materials science Acoustics Process analytical technology Pharmaceutical Science 02 engineering and technology Aquatic Science engineering.material 030226 pharmacology & pharmacy law.invention Compensation (engineering) 03 medical and health sciences 0302 clinical medicine Signal-to-noise ratio Coating law Drug Discovery Technology Pharmaceutical Hot melt coating Particle Size Ecology Evolution Behavior and Systematics Spectroscopy Near-Infrared Ecology Process (computing) Reproducibility of Results General Medicine 021001 nanoscience & nanotechnology Fluidized bed engineering 0210 nano-technology Agronomy and Crop Science |
| Zdroj: | AAPS PharmSciTech. 18:182-193 |
| ISSN: | 1530-9932 |
| Popis: | The aim of the present work was to develop a PAT strategy for the supervision of hot melt coating processes. Optical fibers were placed at various positions in the process chamber of a fluid bed device. Experiments were performed to determine the most suitable position for in-line process monitoring, taking into account such requirements as a good signal to noise ratio, the mitigation of dead zones, the ability to monitor the product over the entire process, and reproducibility. The experimental evidence suggested that the position at medium fluid bed height, looking towards the center, i.e., normal to particle movement, proved to be the most reliable position. In this study, the advantages of multipoint monitoring are shown, and an in-line-implementation was created. This enabled the real-time supervision of the process, including the fast detection of inhomogeneities and disturbances in the process chamber, and the compensation of sensor malfunction. In addition, a model for estimating the particle size distribution via NIR was successfully created. This ensures that the quality of the product and the endpoint of the coating process can be determined correctly. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink