A Pilot Study of Ketamine versus Midazolam/Fentanyl Sedation in Children Undergoing GI Endoscopy
| Autor: | Victor L. Fox, Paul Mitchell, Lisa B. Mahoney, Jenifer R. Lightdale, Meghan E. Fredette, Lisa Scharff, Steven E. Zgleszewski |
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| Rok vydání: | 2010 |
| Předmět: |
Univariate analysis
medicine.medical_specialty Article Subject business.industry Sedation lcsh:RJ1-570 lcsh:Pediatrics Gi endoscopy Fentanyl Surgery Anesthesia Pediatrics Perinatology and Child Health medicine Clinical Study Midazolam Ketamine Laryngospasm medicine.symptom business medicine.drug Gastrointestinal endoscopy |
| Zdroj: | International Journal of Pediatrics International Journal of Pediatrics, Vol 2011 (2011) |
| ISSN: | 1687-9759 |
| Popis: | Background. Ketamine sedation has been found superior by physician report to traditional sedation regimens for pediatric endoscopy.Goal. To objectively compare sedation with ketamine versus midazolam/fentanyl for children undergoing gastrointestinal endoscopy.Study. Patients received one of two regimens and were independently monitored using a standardized rating scale.Results. There were 2 episodes of laryngospasm during ketamine sedation. Univariate analyses showed patients sedated with ketamine () moved more (median 25% of procedure time versus 8%, ) and required similar low levels of restraint (0.83% versus 0.25%, ) as patients sedated with midazolam/fentanyl (). Age-adjusted analyses suggested that patients sedated with ketamine were comparably more quiet ().Conclusions. A pilot trial of ketamine at our institution was associated with episodes of laryngospasm. In addition, children sedated with ketamine moved and required restraint similarly to patients sedated with midazolam/fentanyl. Physician perceptions may be affected by the fact that children who received ketamine were less likely to vocalize distress. |
| Databáze: | OpenAIRE |
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