Ribosome hibernation: a new molecular framework for targeting nonreplicating persisters of mycobacteria
| Autor: | Yunlong Li, Ravi Kiran Koripella, Nilesh K. Banavali, Anil K. Ojha, Rajendra K. Agrawal, Manjuli R. Sharma |
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| Rok vydání: | 2021 |
| Předmět: |
Hibernation
Ribosomal Proteins Tuberculosis medicine.drug_class Antibiotics Antitubercular Agents Review Biology biology.organism_classification medicine.disease Microbiology Ribosome Phenotype Mycobacterium Mycobacterium tuberculosis Zinc Bacterial Proteins Drug Resistance Bacterial medicine Humans Ribosomes |
| Zdroj: | Microbiology (Reading) |
| ISSN: | 1465-2080 |
| Popis: | Treatment of tuberculosis requires a multi-drug regimen administered for at least 6 months. The long-term chemotherapy is attributed in part to a minor subpopulation of nonreplicatingMycobacterium tuberculosiscells that exhibit phenotypic tolerance to antibiotics. The origins of these cells in infected hosts remain unclear. Here we discuss some recent evidence supporting the hypothesis that hibernation of ribosomes inM. tuberculosis,induced by zinc starvation, could be one of the primary mechanisms driving the development of nonreplicating persisters in hosts. We further analyse inconsistencies in previously reported studies to clarify the molecular principles underlying mycobacterial ribosome hibernation. |
| Databáze: | OpenAIRE |
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