Emergence and Spread of Cephalosporin-Resistant Neisseria gonorrhoeae with Mosaic penA Alleles, South Korea, 2012–2017

Autor: Hye Gyung Bae, Kyungwon Lee, Mi Soon Han, Hyukmin Lee, Sun Hwa Lee, Young Hee Suh, Magnus Unemo, Yong Kyun Kim
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Microbiology (medical)
Epidemiology
medicine.drug_class
Cephalosporin
Gonorrhea
cephalosporin
lcsh:Medicine
Drug resistance
Microbial Sensitivity Tests
Biology
Emergence and Spread of Cephalosporin-Resistant Neisseria gonorrhoeae with Mosaic penA Alleles
South Korea
2012–2017
medicine.disease_cause
Communicable Diseases
Emerging
lcsh:Infectious and parasitic diseases
Antibiotic resistance
South Korea
Republic of Korea
medicine
penA
Humans
Penicillin-Binding Proteins
AMR
lcsh:RC109-216
antimicrobial resistance
antimicrobial treatment
bacteria
NG-MAST
sexually transmitted infections
Alleles
cefixime
Cephalosporin Resistance
gonorrhea
Research
lcsh:R
medicine.disease
Virology
Neisseria gonorrhoeae
Anti-Bacterial Agents
Multiple drug resistance
Molecular Typing
ceftriaxone
Infectious Diseases
Multilocus sequence typing
Female
Cefixime
medicine.drug
MLST
Zdroj: Emerging Infectious Diseases, Vol 25, Iss 3, Pp 416-424 (2019)
Emerging Infectious Diseases
ISSN: 1080-6059
1080-6040
Popis: In South Korea, surveillance of antimicrobial drug resistance in Neisseria gonorrhoeae is extremely limited. We describe the emergence and subsequent national spread of N. gonorrhoeae strains with mosaic penA alleles associated with decreased susceptibility and resistance to extended-spectrum cephalosporins. From 2012 through 2017, the proportion of mosaic penA alleles in gonococcal-positive nucleic acid amplification test (NAAT) specimens across South Korea increased from 1.1% to 23.9%. Gonococcal strains with mosaic penA alleles emerged in the international hubs of Seoul in Gyeonggi Province and Busan in South Gyeongsang Province and subsequently spread across South Korea. Most common was mosaic penA-10.001 (n = 572 isolates; 94.7%), which is associated with cefixime resistance. We also identified mosaic penA-34.001 and penA-60.001, both of which are associated with multidrug-resistant gonococcal strains and spread of cefixime and ceftriaxone resistance. Implementation of molecular resistance prediction from N. gonorrhoeae–positive nucleic acid amplification test specimens is imperative in South Korea and internationally.
Databáze: OpenAIRE
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