Urinary PSA: a potential useful marker when serum PSA is between 2.5 ng/mL and 10 ng/mL
Autor: | Stéphane Bolduc, Yves Fradet, Louis Lacombe, Mireille Gregoire, Roland R. Tremblay, Alain Naud |
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Rok vydání: | 2013 |
Předmět: |
Gynecology
medicine.medical_specialty Receiver operating characteristic business.industry Urology Urinary system Urine urologic and male genital diseases medicine.disease Prostate cancer Prostate-specific antigen medicine.anatomical_structure Oncology Prostate medicine Differential diagnosis Prospective cohort study business Original Research |
Zdroj: | Canadian Urological Association Journal. 1:377 |
ISSN: | 1920-1214 1911-6470 |
DOI: | 10.5489/cuaj.444 |
Popis: | Introduction: Our objective was to evaluate the usefulness of urinary prostatespecific antigen (PSA) in the differential diagnosis of benign prostatic hyperplasia(BPH) and prostate cancer.Methods: We undertook a prospective study and obtained informed consent from170 men. They provided blood samples to measure serum PSA and 50 mL of firstvoidedurine to measure urinary PSA. Seventy-seven men were diagnosed with BPH; 42 patients had newly diagnosed prostate cancer; and 51 were selected as age-matched control subjects. Data were analyzed using Wilcoxon signed rank tests, receiver operating characteristic (ROC) curves and logistic regression.Results: Prostate volume was 35 cm3 and 45 cm3 (p < 0.05), serum PSA was9.7 ng/mL and 4.5 ng/mL (p < 0.001) and PSA density was 0.28 and 0.11 (p < 0.01) for prostate cancer and BPH patients, respectively. Overall, urinary PSA was not significantly different, but PSA ratio (urinary:serum) was significantly different at 6.7 and 30.6 (p < 0.001) for prostate cancer and BPH patients, respectively. A subgroup with serum PSA between 2.5 ng/mL and 10.0 ng/mL was selected and urinary PSA was significant: 52.6 ng/mL (n = 29) and 123.2 ng/mL (n = 35) (p < 0.05) for prostate cancer and BPH patients, respectively. PSA ratios were also significant (p = 0.007). ROC curves identified a cutoff for urinary PSA at > 150 ng/mL, with a sensitivity of 92.5%. When comparingprostate cancer patients with age-matched control subjects, serum PSA, urinaryPSA and PSA ratio were different (p = 0.004).Conclusion: Our study supports urinary PSA as a useful marker in the differentialdiagnosis of prostate cancer and BPH, especially when serum PSA is between2.5 ng/mL and 10 ng/mL. Low urinary PSA and PSA ratios point toward prostatecancer. A urinary PSA threshold of > 150 ng/mL may be used to decrease thenumber of prostatic biopsies. |
Databáze: | OpenAIRE |
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