Discovery of common variants associated with low TSH levels and thyroid cancer risk
| Autor: | Simon N. Stacey, Hoskuldur Kristvinsson, Unnur S. Bjornsdottir, Jeffrey R. Gulcher, Hjordis Bjarnason, Unnur Thorsteinsdottir, Theo S. Plantinga, Gisli Masson, Isleifur Olafsson, Thorunn Rafnar, Jose I. Mayordomo, Jon Hrafnkelsson, Laufey Tryggvadottir, Hilma Holm, W. G. Li, Matthew D. Ringel, Almudena García-Castaño, Lambertus A. Kiemeney, Daniel F. Gudbjartsson, Jon G. Jonasson, Angeles Panadero, Thorvaldur Jonsson, Albert de la Chapelle, Enrique Prats, Marieke de Visser, Kristleifur Kristjansson, Richard T. Kloos, Gudmundur I. Eyjolfsson, Aslaug Jonasdottir, Augustine Kong, Julius Gudmundsson, Asgeir Sigurdsson, G. Bragi Walters, Kari Stefansson, Ana de Juan, Fernando Rivera, Esperanza Aguillo, Huiling He, Rebecca Nagy, Gudmar Thorleifsson, Hafdis T. Helgadottir, Olafur T. Magnusson, Romana T. Netea-Maier, Hannes Hjartarson, Martin den Heijer, Patrick Sulem, Hrefna Johannsdottir |
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| Přispěvatelé: | Internal medicine, EMGO - Musculoskeletal health |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Genotype Neuregulin-1 Iceland Thyrotropin Single-nucleotide polymorphism Genome-wide association study Aetiology screening and detection [ONCOL 5] Polymorphism Single Nucleotide Article Invasive mycoses and compromised host [N4i 2] Thyroid-stimulating hormone Polymorphism (computer science) Internal medicine Genetics medicine Humans Hormonal regulation Translational research [IGMD 6] Genetic Predisposition to Disease Thyroid Neoplasms Neuregulin 1 Thyroid cancer Health aging / healthy living Cardiovascular diseases [IGMD 5] Molecular epidemiology Aetiology screening and detection [NCEBP 1] Chromosomes Human Pair 14 biology Thyroid Genetic Variation medicine.disease Endocrinology medicine.anatomical_structure Genetic Loci Chromosomes Human Pair 2 biology.protein Chromosomes Human Pair 8 Genome-Wide Association Study |
| Zdroj: | Gudmundsson, J, Sulem, P, Gudbjartsson, D F, Jonasson, J G, Masson, G, He, H L, Jonasdottir, A, Sigurdsson, A, Stacey, S N, Johannsdottir, H, Helgadottir, H T, Li, W, Nagy, R, Ringel, M D, Kloos, R T, de Visser, M C H, Plantinga, T S, den Heijer, M, Aguillo, E, Panadero, A, Prats, E, Garcia-Castano, A, De Juan, A, Rivera, F, Walters, G B, Bjarnason, H, Tryggvadottir, L, Eyjolfsson, G I, Bjornsdottir, U S, Holm, H, Olafsson, I, Kristjansson, K, Kristvinsson, H, Magnusson, O T, Thorleifsson, G, Gulcher, J R, Kong, A, Kiemeney, L A L M, Jonsson, T, Hjartarson, H, Mayordomo, J I, Netea-Maier, R T, de la Chapelle, A, Hrafnkelsson, J, Thorsteinsdottir, U, Rafnar, T & Stefansson, K 2012, ' Discovery of common variants associated with low TSH levels and thyroid cancer risk ', Nature Genetics, vol. 44, no. 3, pp. 319-322 . https://doi.org/10.1038/ng.1046 Nature Genetics, 44, 3, pp. 319-22 Nature Genetics, 44(3), 319-322. Nature Publishing Group Nature Genetics, 44, 319-22 |
| ISSN: | 1061-4036 |
| DOI: | 10.1038/ng.1046 |
| Popis: | Contains fulltext : 110933.pdf (Publisher’s version ) (Closed access) To search for sequence variants conferring risk of nonmedullary thyroid cancer, we focused our analysis on 22 SNPs with a P < 5 x 10(-8) in a genome-wide association study on levels of thyroid stimulating hormone (TSH) in 27,758 Icelanders. Of those, rs965513 has previously been shown to associate with thyroid cancer. The remaining 21 SNPs were genotyped in 561 Icelandic individuals with thyroid cancer (cases) and up to 40,013 controls. Variants suggestively associated with thyroid cancer (P < 0.05) were genotyped in an additional 595 non-Icelandic cases and 2,604 controls. After combining the results, three variants were shown to associate with thyroid cancer: rs966423 on 2q35 (OR = 1.34; P(combined) = 1.3 x 10(-9)), rs2439302 on 8p12 (OR = 1.36; P(combined) = 2.0 x 10(-9)) and rs116909374 on 14q13.3 (OR = 2.09; P(combined) = 4.6 x 10(-11)), a region previously reported to contain an uncorrelated variant conferring risk of thyroid cancer. A strong association (P = 9.1 x 10(-91)) was observed between rs2439302 on 8p12 and expression of NRG1, which encodes the signaling protein neuregulin 1, in blood. 01 maart 2012 |
| Databáze: | OpenAIRE |
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