Incidence and risk factors of acute kidney injury in the Japanese trauma population: A prospective cohort study

Autor: Akira Kuriyama, Jun Fujinaga, Noriaki Shimada
Rok vydání: 2017
Předmět:
Male
medicine.medical_specialty
Blood transfusion
medicine.medical_treatment
Population
Comorbidity
urologic and male genital diseases
law.invention
03 medical and health sciences
Sex Factors
0302 clinical medicine
Japan
Risk Factors
law
Internal medicine
medicine
Humans
Blood Transfusion
Hospital Mortality
Prospective Studies
030212 general & internal medicine
Intensive care medicine
Prospective cohort study
education
Aged
General Environmental Science
Aged
80 and over
education.field_of_study
Trauma Severity Indices
business.industry
Incidence
Incidence (epidemiology)
Age Factors
Acute kidney injury
030208 emergency & critical care medicine
Odds ratio
Acute Kidney Injury
Middle Aged
medicine.disease
Intensive care unit
female genital diseases and pregnancy complications
Intensive Care Units
Wounds and Injuries
General Earth and Planetary Sciences
Female
business
Kidney disease
Zdroj: Injury. 48:2145-2149
ISSN: 0020-1383
Popis: Previous studies have reported the prevalence and risk factors of acute kidney injury (AKI) in relatively young trauma patients. The aims of this study were to identify the prevalence and risk factors of AKI among older Japanese trauma patients.We conducted a prospective observational study in the 8-bed intensive care unit (ICU) of a Japanese tertiary-care hospital. Participants comprised trauma patients aged 18 years or older admitted to the ICU. Our primary outcome was the incidence of AKI within 10days of admission, according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria.Among 333 patients, 66 (19.8%) developed AKI (Stage 1, n=54; Stages 2, n=5; and Stage 3, n=7). Multivariate logistic regression analysis revealed that the incidence of AKI was associated with increased age (odds ratio (OR), 1.38; 95% confidence interval (CI), 1.15-1.65), male sex (OR, 2.06; 95%CI, 1.04-4.07), greater amount of red blood cell transfusions (OR, 1.61; 95%CI, 1.04-1.17), and presence of underlying chronic kidney disease (CKD) (OR, 3.97; 95%CI, 1.78-8.83). Length of stay in the ICU was significantly longer in patients with AKI (6days) than in those without (3days; p0.001). Patients ≥65 years old were more likely to develop AKI (26.2% vs 11.6%; p0.001). No significant differences in ICU stay (median, 4 vs 4days; p=0.70), hospital stay (median, 24 vs 21days; p=0.45), or 28-day mortality (2.1% vs 1.4%; p=0.19) were evident between age groups.Approximately 20% of trauma patients developed AKI, and the elderly were more likely to develop AKI. Older age, male, greater units of red blood cell transfusions, and underlying CKD were associated with incidence of AKI.
Databáze: OpenAIRE
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