The usefulness of NOR and RFA banding in prenatal diagnosis: A case report
| Autor: | Linda Ekblom, Ming-liang Lee, Barathur R. Rajendra, Emilie Cummings, Leonard J. Sciorra, John M. Opitz |
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| Rok vydání: | 1981 |
| Předmět: |
Adult
Male Male fetus Pathology medicine.medical_specialty Chromosome Disorders Chromosomal translocation Prenatal diagnosis Biology Parental chromosome Translocation Genetic Chromosome 15 Chromosome analysis Pregnancy Prenatal Diagnosis Chromosomes Human 21-22 and Y Nucleolus Organizer Region medicine Humans Genetics (clinical) Chromosome Aberrations Genetics Acridine Orange Chromosome Banding Amniocentesis Female Chromosomes Human 13-15 |
| Zdroj: | American Journal of Medical Genetics. 10:147-149 |
| ISSN: | 1096-8628 0148-7299 |
| DOI: | 10.1002/ajmg.1320100208 |
| Popis: | Prenatal chromosome analysis of amniotic cells showed a male fetus to carry an unusual marker D chromosome containing extra genetic material on the short arm, which could be interpreted as a possible t(D;G) or t(D;Fq) unbalanced translocation using non-branded preparations or a routine GTG band method. Analysis of this marker by NOR and RFA banding and parental chromosome studies showed the marker to be an unusual variant of the satellited area of chromosome 15, with no associated phenotypic anomalies. The usefulness of NOR and RFA banding as aids in chromosome identification in prenatal diagnosis is discussed. |
| Databáze: | OpenAIRE |
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