Influence ofHelicobacter pylori on gastric mucosal adaptation to naproxen in man
| Autor: | G. R. Lipscomb, W. D. W. Rees, N. Wallis, G. Armstrong, M. J. Goodman |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
medicine.medical_specialty Naproxen Adolescent Physiology medicine.medical_treatment Spirillaceae Gastroenterology Helicobacter Infections Internal medicine medicine Humans Antrum Chemotherapy Helicobacter pylori biology business.industry Stomach Anti-Inflammatory Agents Non-Steroidal Drug Tolerance Middle Aged Hepatology biology.organism_classification Adaptation Physiological medicine.anatomical_structure Gastric Mucosa Regional Blood Flow Gastritis Toxicity Immunology business medicine.drug |
| Zdroj: | Digestive Diseases and Sciences. 41:1583-1588 |
| ISSN: | 1573-2568 0163-2116 |
| DOI: | 10.1007/bf02087904 |
| Popis: | Our objective was to determine whether H. pylori influences gastric mucosal injury and adaptation caused by naproxen. Twenty-four healthy volunteers, 12 H. pylori-positive and 12 H. pylori-negative, were given a 28-day course of naproxen 500 mg twice a day. They were each gastroscoped to assess gastric mucosal damage and mucosal blood flow before and at 1, 7, and 28 days during treatment. Maximal gastric mucosal damage (median grade + IQR) occurred during the first 24 hr in both groups and was of similar magnitude (H. pylori-positive: 2.5, 2.0-3.0 P0.01; H. pylori-negative: 2.0, 1.0-3.0 P0.01). This damage was associated with a fall in antral but not corpus mucosal blood flow. With continued NSAID administration, gastric damage resolved confirming adaptation (H. pylori-positive 1.0, 0-2.0, H. pylori-negative: 1.0, 0-1.0) and antral mucosal blood flow returned to baseline in both groups by day 28. These observations suggest that initial gastric mucosal injury is not influenced by H. pylori colonization and adaptation occurs regardless of its presence. |
| Databáze: | OpenAIRE |
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