Pathogen-related factors affecting outcome of catheter-related bacteremia due to methicillin-susceptible Staphylococcus aureus in a Spanish multicenter study
| Autor: | Esther Viedma, Elena Resino-Foz, Rafael San-Juan, M. A. Morales-Cartagena, Miquel Pujol, Alicia Rico, María Pilar Romero, Jesús Fortún, Carmen Ardanuy, Fernando Chaves, Elena Loza, M. Fernández de Mera, Isabel Fernández Morales, Mario Fernández-Ruiz, Mª Angeles Orellana, Francisco López-Medrano, M de Cueto, Antonio Lalueza, José María Aguado, D. Pérez-Montarelo |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male Staphylococcus aureus Virulence Factors 030106 microbiology Virulence Bacteremia medicine.disease_cause Microbiology 03 medical and health sciences medicine Endocarditis Humans Septic thrombophlebitis Prospective Studies Prospective cohort study Aged Aged 80 and over business.industry Hazard ratio General Medicine biochemical phenomena metabolism and nutrition Middle Aged Staphylococcal Infections bacterial infections and mycoses medicine.disease Microarray Analysis Molecular Typing Infectious Diseases Treatment Outcome Spain Catheter-Related Infections bacteria Female Methicillin Susceptible Staphylococcus Aureus business |
| Zdroj: | European journal of clinical microbiologyinfectious diseases : official publication of the European Society of Clinical Microbiology. 36(10) |
| ISSN: | 1435-4373 |
| Popis: | Even with appropriate clinical management, complicated methicillin-susceptible Staphylococcus aureus (MSSA) catheter-related bacteremia (CRB) is frequent. We investigated the influence of molecular characteristics of MSSA strains on the risk of complicated bacteremia (CB) in MSSA-CRB. A multicenter prospective study was conducted in Spain between 2011 and 2014 on MSSA-CRB. Optimized protocol-guided clinical management was required. CB included endocarditis, septic thrombophlebitis, persistent bacteremia and/or end-organ hematogenous spread. Molecular typing, agr functionality and DNA microarray analysis of virulence factors were performed in all MSSA isolates. Out of 83 MSSA-CRB episodes included, 26 (31.3%) developed CB. MSSA isolates belonged to 16 clonal complexes (CCs), with CC30 (32.5%), CC5 (15.7%) and CC45 (13.3) being the most common. Comparison between MSSA isolates in episodes with or without CB revealed no differences regarding agr type and functionality. However, our results showed that CC15 and the presence of genes like cna, chp and cap8 were associated with the development of CB. The multivariate analysis highlighted that the presence of cna (Hazard ratio 2.9; 95% CI 1.14-7.6) was associated with the development of CB. Our results suggest that particular CCs and specific genes may influence the outcome of MSSA-CRB. |
| Databáze: | OpenAIRE |
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