Screening antimutagenic and antiproliferative properties of extracts isolated from Jackfruit pulp (Artocarpus heterophyllus Lam)
| Autor: | Carlos Arturo Velázquez-Contreras, Juan Arturo Ragazzo-Sánchez, Gabriela Ruiz-Montañez, Carmen María López-Saiz, Arturo Navarro-Ocaña, Armando Burgos-Hernández, M. Calderón-Santoyo |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Salmonella Aflatoxin Antioxidant medicine.medical_treatment Drug Evaluation Preclinical Antineoplastic Agents Fractionation medicine.disease_cause Antioxidants Analytical Chemistry Rats Sprague-Dawley Mice Artocarpus Cell Line Tumor Botany medicine Animals Chromatography High Pressure Liquid Traditional medicine biology Mutagenicity Tests Plant Extracts Chemistry Antimutagenic Agents General Medicine biology.organism_classification Rats Chemoprotective Pulp (tooth) Drug Screening Assays Antitumor Cancer cell lines Food Science |
| Zdroj: | Food Chemistry. 175:409-416 |
| ISSN: | 0308-8146 |
| DOI: | 10.1016/j.foodchem.2014.11.122 |
| Popis: | The present focused on the study of the antimutagenic and antiproliferative potential of pulp Jackfruit (Artocarpus heterophyllus Lam) extract, using Salmonella typhimurium tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line M12.C3.F6 (murine B-cell lymphoma), respectively. Jackfruit pulp extract was sequentially fractionated by chromatography (RP-HPLC) and each fraction was tested for antimutagenic and antiproliferative activities. The organic extracts obtained from Jackfruit pulp reduced the number of revertants caused by aflatoxin B1 (AFB1) and proliferation of cells M12.C3.F6; a dose-response relationship was showed. Sequential RP-HPLC fractionation of the active extracts produced both antimutagenic and/or antiproliferative fractions. These results suggested that the Jackfruit contained compounds with chemoprotective properties to reduce the mutagenicity of AFB1, also proliferation of a cancer cell line. |
| Databáze: | OpenAIRE |
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