Antibiotic-Resistant Septicemia in Pediatric Oncology Patients Associated with Post-Therapeutic Neutropenic Fever
Autor: | José Erik Urrutia Favila, Adan Peña Barreto, Ivanka Alejandra Aguilar Velazco, Andrea Ibarra Moreno, Tomás Barrientos Fortes, José Marcos Félix Castro, Sandra Georgina Solano-Gálvez, Juan Antonio González-Barrios, Guadalupe Lizeth Ortega Ortuño, Jorge Andrés Abello Vaamonde, Rosalino Vázquez-López, Omar Rivero Rojas |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Microbiology (medical)
medicine.medical_specialty medicine.medical_treatment Review Biochemistry Microbiology pandrug-resistant (PDR) bacteria Sepsis 03 medical and health sciences 0302 clinical medicine Antibiotic resistance extensively drug-resistant (XDR) bacteria multidrug-resistant (MDR) bacteria medicine childhood cancer Pharmacology (medical) 030212 general & internal medicine General Pharmacology Toxicology and Pharmaceutics Intensive care medicine Mexico post-therapeutic neutropenic fever business.industry Septic shock Incidence (epidemiology) Mortality rate Risk of infection lcsh:RM1-950 septicemia Cancer medicine.disease Radiation therapy Infectious Diseases lcsh:Therapeutics. Pharmacology 030220 oncology & carcinogenesis business |
Zdroj: | Antibiotics Antibiotics, Vol 8, Iss 3, p 106 (2019) |
ISSN: | 2079-6382 |
Popis: | Death in cancer patients can be caused by the progression of tumors, their malignity, or other associated conditions such as sepsis, which is a multiphasic host response to a pathogen that can be significantly amplified by endogenous factors. Its incidence is continuously rising, which reflects the increasing number of sick patients at a higher risk of infection, especially those that are elderly, pediatric, or immunosuppressed. Sepsis appears to be directly associated with oncological treatment and fatal septic shock. Patients with a cancer diagnosis face a much higher risk of infections after being immunosuppressed by chemotherapy, radiotherapy, or anti-inflammatory therapy, especially caused by non-pathogenic, Gram-negative, and multidrug-resistant pathogens. There is a notorious difference between the incidence and mortality rates related to sepsis in pediatric oncologic patients between developed and developing countries: they are much higher in developing countries, where investment for diagnosis and treatment resources, infrastructure, medical specialists, cancer-related control programs, and post-therapeutic care is insufficient. This situation not only limits but also reduces the life expectancy of treated pediatric oncologic patients, and demands higher costs from the healthcare systems. Therefore, efforts must aim to limit the progression of sepsis conditions, applying the most recommended therapeutic regimens as soon as the initial risk factors are clinically evident—or even before they are, as when taking advantage of machine learning prediction systems to analyze data. |
Databáze: | OpenAIRE |
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