Sparse and powerful cortical spikes
| Autor: | Arthur R. Houweling, Michael Brecht, J. H. Wolfe |
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| Přispěvatelé: | Neurosciences |
| Rok vydání: | 2010 |
| Předmět: |
Models
Neurological Action Potentials Somatosensory system Synapse 03 medical and health sciences 0302 clinical medicine Postsynaptic potential Cortex (anatomy) Neural Pathways medicine Animals Sensitivity (control systems) Visual Cortex 030304 developmental biology Neurons Synaptic potential 0303 health sciences General Neuroscience Visual cortex medicine.anatomical_structure Neural Networks Computer Nerve Net Psychology Neural coding Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Current Opinion in Neurobiology Current Opinion in Neurobiology, 20(3), 306-312. Elsevier Ltd. |
| ISSN: | 1873-6882 0959-4388 |
| Popis: | Activity in cortical networks is heterogeneous, sparse and often precisely timed. The functional significance of sparseness and precise spike timing is debated, but our understanding of the developmental and synaptic mechanisms that shape neuronal discharge patterns has improved. Evidence for highly specialized, selective and abstract cortical response properties is accumulating. Singe-cell stimulation experiments demonstrate a high sensitivity of cortical networks to the action potentials of some, but not all, single neurons. It is unclear how this sensitivity of cortical networks to small perturbations comes about and whether it is a generic property of cortex. The unforeseen sensitivity to cortical spikes puts serious constraints on the nature of neural coding schemes. |
| Databáze: | OpenAIRE |
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