High-performance liquid chromatographic and subcritical fluid chromatographic separation of α-arylated ß-carboline, N-alkylated tetrahydroisoquinolines and their bioisosteres on polysaccharide-based chiral stationary phases
| Autor: | Ferenc Fülöp, Attila Bajtai, Gábor Németi, Antal Péter, Gyula Lajkó, István Ilisz, István Szatmári |
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| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Chromatography 010405 organic chemistry Tetrahydroisoquinoline 010401 analytical chemistry Filtration and Separation Alkylation Polysaccharide 01 natural sciences High-performance liquid chromatography 0104 chemical sciences Analytical Chemistry Solvent chemistry.chemical_compound Chromatographic separation chemistry Azepine Enantiomer |
| Zdroj: | Journal of separation scienceREFERENCES. 42(17) |
| ISSN: | 1615-9314 |
| Popis: | New, pharmacologically interesting chiral amino compounds, namely, stereoisomers of α-hydroxynaphthyl-s-carboline, benz[d]azepine and benz[c]azepine analogs as well as N-α-hydroxynaphthylbenzyl-substituted isoquinolines were enantioseparated by high-performance liquid chromatographic and subcritical fluid chromatographic methods on polysaccharide-based chiral stationary phases. Separation of the stereoisomers was optimized in both subcritical fluid chromatography and normal phase liquid chromatographic modes by investigating the effects of the composition of the bulk solvent, temperature, and the structures of the analytes and selectors. Both normal phase liquid chromatography and subcritical fluid chromatography exhibited satisfactory performance, albeit with somewhat different effectiveness in the separation of the stereoisomers studied. The optimized methods offer the possibility to apply preparative-scale separations thereby enabling further pharmacological investigations of the enantiomers. |
| Databáze: | OpenAIRE |
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