The effect of local injection of methylprednisolone acetate on the hypothalamic-pituitary-adrenal axis among patients with greater trochanteric pain syndrome

Autor: Suheil Artul, Haneen Jabaly-Habib, George Habib, Shada Elias, Fadi Khazin, Muhanned Abu-Elhaija, Adel Jabbour, Fahed Sakas
Rok vydání: 2016
Předmět:
Male
Hypothalamo-Hypophyseal System
medicine.medical_specialty
Hydrocortisone
medicine.drug_class
Pituitary-Adrenal System
Stimulation
Greater trochanteric pain syndrome
Methylprednisolone
Injections
03 medical and health sciences
Basal (phylogenetics)
0302 clinical medicine
Adrenocorticotropic Hormone
Rheumatology
Internal medicine
medicine
Humans
Femur
Prospective Studies
030212 general & internal medicine
Israel
Somatoform Disorders
030203 arthritis & rheumatology
medicine.diagnostic_test
business.industry
ACTH stimulation test
General Medicine
Middle Aged
Methylprednisolone acetate
medicine.disease
Methylprednisolone Acetate
Logistic Models
Treatment Outcome
Endocrinology
medicine.anatomical_structure
Anesthesia
Multivariate Analysis
Corticosteroid
Female
business
Hypothalamic–pituitary–adrenal axis
Adrenal Insufficiency
Zdroj: Clinical Rheumatology. 36:959-963
ISSN: 1434-9949
0770-3198
DOI: 10.1007/s10067-016-3517-1
Popis: Greater trochanteric pain syndrome (GTPS) is a common clinical entity for which the most effective treatment is local corticosteroid injection (LCI). There are no studies on the effect of LCI among patients with GTPS on the hypothalamic-pituitary-adrenal axis. The present study recruited nonselected patients diagnosed with GTPS. After consenting, participants received low dose (1 μg) of adrenocorticotropin hormone (ACTH) stimulation test at 09:00. Immediately following the test, participants received a LCI of 80 mg of methylprednisolone acetate at the greater trochanteric region. The ACTH stimulation test was repeated 1, 2, 4, and 6 weeks following the LCI. Cortisol samples were obtained at just prior to (basal) and 30 min (post-stimulation) following every ACTH stimulation test. Serum cortisol levels of
Databáze: OpenAIRE
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