Consolidation Radiotherapy Could Be Safely Omitted in Advanced Hodgkin Lymphoma With Large Nodal Mass in Complete Metabolic Response After ABVD: Final Analysis of the Randomized GITIL/FIL HD0607 Trial
| Autor: | Federico Fallanca, Roberto Sorasio, Umberto Ficola, Silvia Bolis, Guido Gini, Simonetta Viviani, Alessandra Romano, Piera Viero, Roberta Zanotti, Michele Cimminiello, Luca Guerra, Sara Oppi, Andrea Gallamini, Alessandro Rambaldi, Caterina Patti, Marco Picardi, Roberta Battistini, Livio Trentin, Andrea Rossi, Corrado Tarella, Corrado Schiavotto, Antonino Mulè, Maria Cantonetti, Chiara Pavoni, Stephane Chauvie |
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| Přispěvatelé: | Gallamini, Andrea, Rossi, Andrea, Patti, Caterina, Picardi, Marco, Romano, Alessandra, Cantonetti, Maria, Oppi, Sara, Viviani, Simonetta, Bolis, Silvia, Trentin, Livio, Gini, Guido, Battistini, Roberta, Chauvie, Stephane, Sorasio, Roberto, Pavoni, Chiara, Zanotti, Roberta, Cimminiello, Michele, Schiavotto, Corrado, Viero, Piera, Mulé, Antonino, Fallanca, Federico, Ficola, Umberto, Tarella, Corrado, Guerra, Luca, Rambaldi, Alessandro, Gallamini, A, Rossi, A, Patti, C, Picardi, M, Romano, A, Cantonetti, M, Oppi, S, Viviani, S, Bolis, S, Trentin, L, Gini, G, Battistini, R, Chauvie, S, Sorasio, R, Pavoni, C, Zanotti, R, Cimminiello, M, Schiavotto, C, Viero, P, Mulé, A, Fallanca, F, Ficola, U, Tarella, C, Guerra, L, Rambaldi, A |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent Lymphoma medicine.medical_treatment Kaplan-Meier Estimate Vinblastine law.invention Bleomycin Young Adult 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Antineoplastic Combined Chemotherapy Protocols Humans Medicine Prospective Studies Progression-free survival Young adult Prospective cohort study radiotherapy Neoplasm Staging business.industry hodgkin lymphoma Middle Aged medicine.disease Hodgkin Disease Progression-Free Survival Dacarbazine Radiation therapy Oncology ABVD Doxorubicin 030220 oncology & carcinogenesis Hodgkin lymphoma Female Lymph Nodes Radiology business 030215 immunology medicine.drug |
| Popis: | PURPOSE To investigate the role of consolidation radiotherapy (cRT) in advanced-stage Hodgkin lymphoma (HL) presenting at baseline with a large nodal mass (LNM) in complete metabolic response after doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) chemotherapy. PATIENTS AND METHODS Advanced-stage (IIB-IVB) HL patients, enrolled in the HD 0607 trial (Clinicaltrial.gov identifier NCT00795613 ), with both a negative PET after two (PET-2) and six (PET-6) ABVD cycles, who presented at baseline with an LNM, defined as a nodal mass with the largest diameter ≥ 5 cm, were prospectively randomly assigned to receive cRT over the LNM or no further treatment (NFT). RESULTS Among 296 randomly assigned patients, the largest diameter of LNM at baseline was 5-7 cm in 101 (34%; subgroup A) and 8-10 cm in 96 (32%; subgroup B), whereas classic bulky (diameter > 10 cm) was detected in 99 (33%; subgroup C). Two hundred eighty patients (88%) showed a postchemotherapy RM. The median dose of cRT was 30.6 Gy (range, 24-36 Gy). After a median follow-up of 5.9 years (range, 0.5-10 years), the 6-year progression-free survival rate of patients who underwent cRT or NFT was, respectively, 91% (95% CI, 84% to 99%) and 95% (95% CI, 89% to 100%; P = .62) in subgroup A; 98% (95% CI, 93% to 100%) and 90% (95% CI, 80% to 100%; P = .24) in subgroup B; 89% (95% CI, 81% to 98%) and 86% (95% CI, 77% to 96%; P = .53) in subgroup C (classic bulky). CONCLUSION cRT could be safely omitted in patients with HL presenting with an LNM and a negative PET-2 and PET-6 scan, irrespective from the LNM size detected at baseline. |
| Databáze: | OpenAIRE |
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