Extrudable core system: Development of a single-layer osmotic controlled-release tablet
| Autor: | Bruce C. MacDonald, Kenneth Craig Waterman, Michael Christopher Roy |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Osmosis
Materials science Polymers Drug Compounding Administration Oral Pharmaceutical Science Core (manufacturing) engineering.material Pharmacology Dosage form Coating Solubility Cellulose Active ingredient Drug Carriers Viscosity Hydrogen-Ion Concentration bacterial infections and mycoses equipment and supplies Chemical engineering Delayed-Action Preparations engineering Core system Single-core Tablets |
| Zdroj: | Journal of Controlled Release. 134:201-206 |
| ISSN: | 0168-3659 |
| Popis: | A new controlled-release, extrudable core system (ECS) tablet has been developed which osmotically delivers high doses of low solubility active pharmaceutical ingredients (API's). The tablet has a single core formed in a modified oval shape with a semi-permeable coating. The core contains hydroxyethylcellulose, which serves to entrain the API particles as they are extruded out a hole in the coating at one end of the tablet, and a sugar, which provides the osmotic driving force for water imbibing. The dosage form has been successfully shown to control delivery of API over a range of delivery rates even with 50% of the tablet being API (up to about 500 mg). |
| Databáze: | OpenAIRE |
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