Genetic Determinants of Telomere Length in African American Youth
| Autor: | Jonathan Witonsky, Marquitta J. White, Kirsten Bibbins-Domingo, Jennifer R. Elhawary, Adam Davis, Joaquin Magana, Harold J. Farber, Donglei Hu, Scott Huntsman, Maria G. Contreras, Eunice Y. Lee, Emerita Brigino-Buenaventura, Oona Risse-Adams, Kevin L. Keys, Lesly-Anne Samedy, Angel C.Y. Mak, Sam S. Oh, Sandra Salazar, Michael A. LeNoir, Andrew M. Zeiger, Celeste Eng, Pagé C. Goddard, Esteban G. Burchard, Kelley Meade, Luisa N. Borrell |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male lcsh:Medicine Genome-wide association study Disease 0302 clinical medicine Polymorphism (computer science) 2.1 Biological and endogenous factors Young adult Aetiology lcsh:Science Child Pediatric African american Genetics African Americans 0303 health sciences education.field_of_study Multidisciplinary Single Nucleotide Telomere Female Asian Continental Ancestry Group Adolescent Population European Continental Ancestry Group Quantitative trait locus Biology Polymorphism Single Nucleotide Article White People 03 medical and health sciences Young Adult Asian People Clinical Research Humans Genetic Predisposition to Disease Polymorphism education 030304 developmental biology Human Genome lcsh:R Genetic variants Chromosome Genetic Variation Telomere Homeostasis Black or African American 030104 developmental biology Genetic marker lcsh:Q 030217 neurology & neurosurgery Demography Genome-Wide Association Study |
| Zdroj: | Scientific reports, vol 8, iss 1 Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018) Scientific Reports |
| Popis: | Telomere length (TL) is associated with numerous disease states and is affected by genetic and environmental factors. However, TL has been mostly studied in adult populations of European or Asian ancestry. These studies have identified 34 TL-associated genetic variants recently used as genetic proxies for TL. The generalizability of these associations to pediatric populations and racially diverse populations, specifically of African ancestry, remains unclear. Furthermore, six novel variants associated with TL in a population of European children have been identified but not validated. We measured TL from whole blood samples of 492 healthy African American youth (children and adolescents between 8 and 20 years old) and performed the first genome-wide association study of TL in this population. We were unable to replicate neither the 34 reported genetic associations found in adults nor the six genetic associations found in European children. However, we discovered a novel genome-wide significant association between TL and rs1483898 on chromosome 14. Our results underscore the importance of examining these genetic associations with TL in diverse pediatric populations such as African Americans. |
| Databáze: | OpenAIRE |
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